DAF-12 Activators
DAF-12 activators represent a distinct class of chemical compounds that play a pivotal role in the regulation of developmental processes in nematodes, particularly in the model organism Caenorhabditis elegans. The term DAF-12 refers to a nuclear hormone receptor that orchestrates a wide array of physiological responses in these tiny roundworms. Structurally, DAF-12 belongs to the nuclear receptor superfamily, sharing homology with vertebrate steroid hormone receptors. DAF-12 is a ligand-activated transcription factor, and its activity is modulated by binding to specific endogenous ligands or exogenous compounds known as DAF-12 activators.
These activators exhibit a remarkable capacity to influence the nematode's life cycle, including aspects of development, reproduction, and longevity. The activation of DAF-12 is crucial for the proper execution of the alternative larval developmental pathways, regulating the transition between larval stages and the decision to enter either reproductive or diapause states. DAF-12 activators exert their effects by binding to the ligand-binding domain of the receptor, thereby triggering a cascade of molecular events that culminate in the modulation of gene expression. Notably, the diversity of DAF-12 activators extends beyond endogenous ligands to include synthetic compounds, expanding the repertoire of molecules that can influence the intricate developmental processes in C. elegans. The study of DAF-12 activators provides a unique lens through which researchers can unravel the intricacies of hormonal signaling pathways and gain insights into the fundamental mechanisms governing the development and life history of nematodes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to and activates retinoid receptors, which can directly enhance the transcriptional activity of DAF-12 as it is a nuclear hormone receptor for retinoids. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $83.00 $272.00 | 1 | |
Lithocholic acid is a bile acid that can act as a ligand for nuclear receptors and may enhance the activation of DAF-12 by binding to it. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $85.00 $145.00 $340.00 $1100.00 | ||
Pregnenolone is a steroid hormone precursor that can be metabolized into ligands for DAF-12, facilitating its activation in steroidogenesis pathways. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $109.00 | 3 | |
DHEA, a steroid hormone, can be transformed into other steroid ligands that engage and enhance the activity of DAF-12 in hormonal signaling. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate is a fibrate drug that activates Peroxisome proliferator-activated receptors (PPARs) which can upregulate the expression of genes involved in lipid metabolism, potentially enhancing DAF-12 activity indirectly through lipid signaling pathways. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $87.00 $220.00 | 5 | |
T0901317 is a synthetic ligand for liver X receptors (LXRs) which could enhance the expression of genes involved in lipid and cholesterol metabolism, indirectly influencing the activity of DAF-12. | ||||||
GW 3965 hydrochloride | 405911-17-3 | sc-224011 sc-224011A sc-224011B | 5 mg 25 mg 1 g | $137.00 $474.00 $3060.00 | ||
GW 3965 is another LXR agonist that can modulate cholesterol homeostasis, potentially impacting DAF-12's activity through alterations in steroid hormone synthesis. | ||||||
L-165041 | 79558-09-1 | sc-203094 | 5 mg | $153.00 | ||
L-165041 is a selective peroxisome proliferator-activated receptor β/δ (PPARδ) agonist that can influence lipid metabolism and thereby may indirectly enhance DAF-12 activity. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14643 is a PPARα agonist that can modulate lipid metabolism, which may indirectly enhance the activation of DAF-12 through alterations in the pool of steroid precursors. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT 5720 is a protein kinase inhibitor that could enhance DAF-12 activity by inhibiting kinases that phosphorylate proteins involved in DAF-12 regulation. | ||||||