D53 Inhibitors
D53 inhibitors are a class of chemical compounds that specifically target the D53 protein, a key repressor in the strigolactone signaling pathway of plants. The D53 protein plays a crucial role in regulating plant architecture by controlling processes such as shoot branching and root development. By inhibiting D53, these compounds modulate the strigolactone pathway, leading to alterations in gene expression that affect plant growth patterns. The inhibition of D53 disrupts its interaction with other signaling molecules like DWARF14 (D14) and SUPPRESSOR OF MAX2 1 (SMXL proteins), which are essential for normal strigolactone perception and response.
Chemically, D53 inhibitors encompass a diverse range of structures, often designed to mimic or interfere with natural ligands within the strigolactone pathway. These compounds may include synthetic analogs of strigolactones or molecules featuring functional groups that enable strong binding to the D53 protein. The design of these inhibitors involves detailed structural analysis of D53 to identify critical binding sites and interaction domains. Techniques such as X-ray crystallography and molecular docking simulations are instrumental in optimizing these compounds for enhanced affinity and specificity. By fine-tuning molecular features like hydrophobicity, electronic distribution, and steric factors, researchers aim to develop D53 inhibitors that effectively modulate the protein's activity, contributing to a deeper understanding of plant growth regulation at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate D53 expression by modifying the acetylation status of histones associated with the D53 gene, leading to tighter chromatin and lower transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By causing hypomethylation of the D53 gene promoter, 5-Azacytidine could reduce the transcriptional initiation of the D53 gene, leading to decreased mRNA and protein levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This chemical can bind specifically to the DNA at the transcription initiation complex and inhibit the elongation phase of RNA synthesis, leading to reduced levels of D53 transcripts. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide might indirectly decrease D53 protein synthesis by blocking the peptidyl transferase activity of the ribosome, which halts mRNA translation elongation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could downregulate D53 by inhibiting the mTOR pathway, which is essential for cap-dependent mRNA translation, thereby reducing D53 protein synthesis. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 may indirectly reduce D53 expression by inhibiting the ubiquitin-proteasome pathway, which might stabilize negative regulators of D53 gene transcription. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
As a JNK inhibitor, SP600125 could decrease D53 expression by inhibiting the JNK signaling cascade, which may be necessary for the transcription of the D53 gene. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 could downregulate D53 by selectively inhibiting p38 MAP kinase, which is potentially involved in the transcriptional regulation of the D53 gene. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 may decrease D53 expression by inhibiting PI3K, leading to a reduction in AKT-mediated signaling pathways that promote D53 gene transcription. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
By inhibiting the production of Wnt proteins, Wnt-C59 could lead to a decrease in D53 expression due to the role of Wnt signaling in gene transcription regulation. | ||||||