Cypin Activators is a chemical class that encompasses various compounds with the potential to directly or indirectly stimulate the activity of guanine deaminase, also known as Cypin. This enzyme plays a significant role in purine metabolism, catalyzing the conversion of guanine to xanthine, a process that results in the release of ammonia. Direct Cypin activators are compounds that can enhance the enzyme's activity by binding to it. This binding may either increase the enzyme's affinity for its natural substrate (guanine) or may stimulate the catalytic activity of the enzyme itself. Such activators often have structures similar to the natural substrate of the enzyme, which allows them to bind to the active site of the enzyme and increase its activity. On the other hand, indirect Cypin activators are compounds that increase the enzyme's activity by altering the concentration or availability of its substrates or products within the cell.
The indirect activators, in particular, can have complex effects due to their interaction with multiple components of the purine metabolic pathway. Despite this complexity, the study of Cypin activators provides valuable insights into the regulation of guanine deaminase and the broader purine metabolic pathway. This knowledge can expand our understanding of cellular metabolism and the intricate balance of enzymatic reactions that maintain cellular function.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR, an intermediate in purine metabolism, may stimulate guanine deaminase (Cypin) indirectly by increasing substrate availability. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
MPA could indirectly promote guanine deaminase (Cypin) activity by inhibiting inosine monophosphate dehydrogenase and potentially increasing guanine concentrations. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
By inhibiting xanthine oxidase and potentially increasing xanthine concentrations, Allopurinol could indirectly spur guanine deaminase (Cypin) activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate may indirectly stimulate guanine deaminase (Cypin) activity by inhibiting dihydrofolate reductase and potentially influencing purine nucleotide synthesis. | ||||||
Azathioprine | 446-86-6 | sc-210853D sc-210853 sc-210853A sc-210853B sc-210853C | 500 mg 1 g 2 g 5 g 10 g | $199.00 $173.00 $342.00 $495.00 $690.00 | 1 | |
Azathioprine, by being metabolized to 6-mercaptopurine (an inhibitor of purine synthesis), could indirectly stimulate guanine deaminase (Cypin) activity. | ||||||
Febuxostat | 144060-53-7 | sc-207680 | 10 mg | $168.00 | 3 | |
Febuxostat could indirectly provoke guanine deaminase (Cypin) activity by inhibiting xanthine oxidase and potentially increasing xanthine concentrations. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
6-Thioguanine, a guanine analog, may indirectly stimulate guanine deaminase (Cypin) activity by potentially competing with guanine for binding. | ||||||
Adenine, cell culture grade | 73-24-5 | sc-291834 sc-291834A sc-291834B | 5 g 25 g 100 g | $82.00 $206.00 $546.00 | 2 | |
As a purine base, Adenine could indirectly stimulate guanine deaminase (Cypin) activity by contributing to the pool of purine metabolites. | ||||||
Hypoxanthine | 68-94-0 | sc-29068 | 25 g | $68.00 | 3 | |
Hypoxanthine, a key intermediate in purine metabolism, may indirectly spur guanine deaminase (Cypin) activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Being metabolized to inosine and hypoxanthine, Adenosine may indirectly stimulate guanine deaminase (Cypin) activity. |