Cypin Antibody (D-7): sc-393571
- Cypin Antibody (D-7) is a mouse monoclonal IgG2a κ Cypin antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 399-424 near the C-terminus of Cypin of human origin
- Cypin Antibody (D-7) is recommended for detection of Cypin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Cypin Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cypin Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Cypin Antibody (D-7) (see ordering information below).
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SEE ALSO...
Cypin Antibody (D-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cypin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Cypin (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cypin, also known as Cytoplasmic PSD-95 interactor, guanine deaminase, and nedasin S, plays a crucial role in regulating synaptic protein sorting, particularly in clustering membrane-associated guanylate kinase (MAGUK) proteins at synaptic sites. Cypin is predominantly located in the cytoplasm of dendritic shafts and synaptic spine necks, where Cypin facilitates assembly of neurotransmitter receptors and associated signaling machinery, vital for effective synaptic transmission and plasticity. Cypin is expressed in non-neuronal cells, with significant levels found in the basal membrane of intestinal epithelial cells, kidney, liver, lung, brain, and spleen, while lower expression levels are observed in placenta, heart, and skeletal muscle. Native Cypin can exist as both a dimer and tetramer, which may influence functional interactions and regulatory mechanisms within cells.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cypin Antibody (D-7) References:
- Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. | Yuan, G., et al. 1999. J Biol Chem. 274: 8175-80. PMID: 10075721
- A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor. | Kuwahara, H., et al. 1999. J Biol Chem. 274: 32204-14. PMID: 10542258
- Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting. | Firestein, BL., et al. 1999. Neuron. 24: 659-72. PMID: 10595517
- Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. | Kim, E., et al. 1995. Nature. 378: 85-8. PMID: 7477295
- Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. | Kornau, HC., et al. 1995. Science. 269: 1737-40. PMID: 7569905
- Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. | Brenman, JE., et al. 1996. Cell. 84: 757-67. PMID: 8625413
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cypin Antibody (D-7) | sc-393571 | 200 µg/ml | $316.00 | |||
Cypin Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-530502 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cypin Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-524003 | 200 µg Ab, 40 µg BP | $354.00 | |||
Cypin Antibody (D-7): m-IgG2a BP-HRP Bundle | sc-547511 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cypin Antibody (D-7) AC | sc-393571 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cypin Antibody (D-7) HRP | sc-393571 HRP | 200 µg/ml | $316.00 | |||
Cypin Antibody (D-7) FITC | sc-393571 FITC | 200 µg/ml | $330.00 | |||
Cypin Antibody (D-7) PE | sc-393571 PE | 200 µg/ml | $343.00 | |||
Cypin Antibody (D-7) Alexa Fluor® 488 | sc-393571 AF488 | 200 µg/ml | $357.00 | |||
Cypin Antibody (D-7) Alexa Fluor® 546 | sc-393571 AF546 | 200 µg/ml | $357.00 | |||
Cypin Antibody (D-7) Alexa Fluor® 594 | sc-393571 AF594 | 200 µg/ml | $357.00 | |||
Cypin Antibody (D-7) Alexa Fluor® 647 | sc-393571 AF647 | 200 µg/ml | $357.00 | |||
Cypin Antibody (D-7) Alexa Fluor® 680 | sc-393571 AF680 | 200 µg/ml | $357.00 | |||
Cypin Antibody (D-7) Alexa Fluor® 790 | sc-393571 AF790 | 200 µg/ml | $357.00 | |||
Cypin (D-7) Neutralizing Peptide | sc-393571 P | 100 µg/0.5 ml | $68.00 |