CYP4A11 Activators
CYP4A11 Activators can be classified into two main categories: Peroxisome proliferator-activated receptor alpha (PPARα) agonists and polyunsaturated fatty acids. PPARα agonists such as Clofibrate, Fenofibrate, Wy-14643, Bezafibrate, Gemfibrozil, and GW7647 act by activating PPARα, a nuclear receptor that is known to regulate the transcription of CYP4A11. Activation of PPARα enhances the expression and function of CYP4A11, thereby increasing its activity. These activators have a direct effect on the activity of CYP4A11 by enhancing its transcription via PPARα activation, a pathway that is directly involved in the regulation of CYP4A11.
On the other hand, polyunsaturated fatty acids like Arachidonic Acid, Linoleic Acid, α-Linolenic Acid, Eicosapentaenoic Acid, Docosahexaenoic Acid, and γ-Linolenic Acid serve as substrates forCYP4A11. They enhance the functional activity of CYP4A11 by providing more substrate for the enzyme to metabolize. These fatty acids increase the rate of conversion of fatty acids into eicosanoids, a process that is directly mediated by CYP4A11. Therefore, an increase in the levels of these fatty acids can enhance the functional activity of CYP4A11 by providing more substrate for the enzyme to process. These chemicals exert a direct influence on the activity of CYP4A11 by increasing the availability of substrates for the enzyme to metabolize, thereby enhancing its function. These polyunsaturated fatty acids and PPARα agonists provide two distinct yet effective ways of activating CYP4A11, each acting through unique and specific signaling pathways or biological processes that directly involve CYP4A11.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. Activation of PPARα can upregulate CYP4A11 expression and activity, as this receptor is known to regulate the transcription of CYP4A11. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate is another PPARα agonist. By activating PPARα, fenofibrate can increase CYP4A11 activity, as PPARα is a known regulator of CYP4A11 transcription. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
Wy-14643 is a potent PPARα agonist. It activates PPARα, which in turn can enhance the function of CYP4A11, as PPARα is involved in the regulation of CYP4A11 transcription. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a PPARα agonist. It can increase CYP4A11 activity by activating PPARα, which is known to regulate CYP4A11 transcription. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil is a fibric acid derivative and a PPARα agonist. It can enhance the function of CYP4A11 by activating PPARα, which is a known regulator of CYP4A11 transcription. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW7647 is a highly potent and selective PPARα agonist. By activating PPARα, GW7647 can increase the activity of CYP4A11, a protein that is transcriptionally regulated by PPARα. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid is a polyunsaturated fatty acid that is a substrate for CYP4A11. Increased levels of arachidonic acid can enhance the functional activity of CYP4A11 by providing more substrate for the enzyme to convert into eicosanoids. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid is a polyunsaturated fatty acid that serves as a substrate for CYP4A11. An increase in linoleic acid can enhance CYP4A11 activity by providing more substrate for the enzyme to metabolize. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
α-Linolenic Acid is a polyunsaturated fatty acid that is a substrate for CYP4A11. Increased levels of α-linolenic acid can increase CYP4A11 activity by providing more substrate for the enzyme to process. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
Eicosapentaenoic Acid is a polyunsaturated fatty acid that is a substrate for CYP4A11. By providing more substrate, increased levels of eicosapentaenoic acid can enhance the activity of CYP4A11. | ||||||