Cyp3a41a Activators
Cyp3a41a, a member of the cytochrome P450 enzyme family, plays a pivotal role in the intricate network of cellular responses to external stimuli, particularly in xenobiotic metabolism and the regulation of gene expression. This enzyme is multifunctional, exhibiting caffeine oxidase, iron ion binding, and monooxygenase activities. Located in the endoplasmic reticulum membrane, Cyp3a41a is expressed in the liver and acts upstream in the regulation of gene expression and the cellular response to bacteria. The orthologous genes in humans, such as CYP3A4 and CYP3A5, are implicated in various conditions, including leukemia, essential hypertension, and familial Mediterranean fever, highlighting the significance of understanding the activation mechanisms of this enzyme.
The activation of Cyp3a41a involves a diverse array of chemicals that act as direct or indirect activators. Direct activators engage with specific receptors, such as the pregnane X receptor (PXR), leading to the upregulation of Cyp3a41a expression. These chemicals enhance the enzyme's caffeine oxidase, iron ion binding, and monooxygenase activities, crucial for its role in xenobiotic metabolism. Indirect activators, on the other hand, modulate intricate cellular pathways like the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway or the sirtuin 1 (SIRT1) pathway, contributing to the amplification of Cyp3a41a activities. The complexity of the activation mechanisms emphasizes the adaptability of Cyp3a41a in responding to a variety of stimuli and maintaining cellular homeostasis. In summary, the intricate interplay of chemical activators ensures the fine-tuned regulation of Cyp3a41a, underlining its essential role in cellular detoxification and environmental response.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, a known activator, interacts with nuclear receptors, particularly the pregnane X receptor (PXR), inducing the upregulation of Cyp3a41a. This activation enhances the enzyme's monooxygenase and iron ion binding activities, crucial for xenobiotic metabolism. | ||||||
Hyperforin | 11079-53-1 | sc-507549 | 250 µg | $420.00 | ||
Hyperforin, a natural compound, induces Cyp3a41a expression via pregnane X receptor (PXR) activation. This leads to enhanced caffeine oxidase and monooxygenase activities, contributing to the metabolism of various substances in the endoplasmic reticulum membrane. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly activates Cyp3a41a by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This indirect activation amplifies iron ion binding and monooxygenase activities, playing a role in regulating responses to bacteria and gene expression. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $171.00 | 3 | |
Efavirenz, a pharmacological agent, acts as a direct activator of Cyp3a41a, engaging with pregnane X receptor (PXR). This interaction leads to the upregulation of caffeine oxidase and iron ion binding activities, contributing to the enzyme's role in xenobiotic metabolism. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole directly activates Cyp3a41a by binding to the pregnane X receptor (PXR). This activation enhances the enzyme's caffeine oxidase and monooxygenase activities, crucial for the metabolism of diverse substrates within the endoplasmic reticulum membrane. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, indirectly activates Cyp3a41a by influencing the sirtuin 1 (SIRT1) pathway. This activation enhances caffeine oxidase and iron ion binding activities, playing a role in the regulation of gene expression and responses to bacteria. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole acts as a direct activator of Cyp3a41a, engaging with the pregnane X receptor (PXR). This interaction leads to the upregulation of monooxygenase and iron ion binding activities, crucial for the enzyme's role in xenobiotic metabolism within the endoplasmic reticulum membrane. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin indirectly activates Cyp3a41a by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This activation amplifies caffeine oxidase and monooxygenase activities, contributing to the enzyme's role in xenobiotic metabolism and cellular responses to bacteria. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole, a known pharmacological agent, acts as a direct activator of Cyp3a41a, binding to the pregnane X receptor (PXR). This activation enhances the enzyme's caffeine oxidase and iron ion binding activities, crucial for xenobiotic metabolism within the endoplasmic reticulum membrane. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin indirectly activates Cyp3a41a by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This activation amplifies caffeine oxidase and monooxygenase activities, contributing to the enzyme's role in xenobiotic metabolism and cellular responses to bacteria. | ||||||