CYP2J7 Activators
CYP2J7, belonging to the cytochrome P450 family, manifests a diverse range of predicted enzymatic activities, prominently featuring heme binding, oxidoreductase, and steroid hydroxylase functions. Situated within the cytoplasm and intracellular membrane-bounded organelles, this enzyme is intricately involved in vital cellular processes, specifically organic acid metabolic pathways and xenobiotic metabolism. The functional significance of CYP2J7 resides in its ability to contribute to the transformation and detoxification of both endogenous and exogenous compounds, playing a crucial role in maintaining cellular homeostasis.
The activation of CYP2J7 unfolds through a sophisticated interplay of direct and indirect mechanisms, orchestrating its enzymatic activities. Direct activators engage with specific regulatory elements, leading to the upregulation of heme binding, oxidoreductase, and steroid hydroxylase activities. These interactions, exemplified by chemicals like rifampicin and auranofin, directly enhance the enzymatic functionality of CYP2J7, facilitating its role in xenobiotic metabolism. On the other hand, indirect activators, exemplified by compounds such as 5-aminosalicylic acid (5-ASA) and dexamethasone, modulate critical signaling pathways like Nrf2-ARE and glucocorticoid receptor, influencing the transcriptional machinery that governs CYP2J7 expression. This nuanced regulation leads to increased heme binding and oxidoreductase activities, accentuating the multifaceted role of CYP2J7 in cellular processes. The dynamic interplay of direct and indirect activators illuminates the adaptability of CYP2J7 in responding to various cellular cues, underscoring its intricate involvement in the metabolic intricacies of organic acids and xenobiotics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin serves as a direct activator of CYP2J7, promoting the upregulation of heme binding and oxidoreductase activities. Its interaction with CYP2J7 leads to increased enzymatic activity, facilitating the steroid hydroxylase activity and contributing to xenobiotic metabolism. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin serves as a direct activator of CYP2J7, promoting the upregulation of heme binding and oxidoreductase activities. This direct interaction enhances enzymatic activity, facilitating steroid hydroxylase activity and contributing to xenobiotic metabolism. | ||||||
5-Aminosalicylic acid | 89-57-6 | sc-202890 | 5 g | $27.00 | 4 | |
5-ASA acts as an indirect activator of CYP2J7 by influencing the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J7 transcription, leading to increased expression and elevated heme binding and oxidoreductase activities, facilitating steroid hydroxylase activity and xenobiotic metabolism. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone serves as an indirect activator of CYP2J7 through its modulation of the glucocorticoid receptor signaling pathway. Activation of this pathway enhances CYP2J7 transcription, leading to increased expression and elevated heme binding and oxidoreductase activities, facilitating steroid hydroxylase activity and xenobiotic metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol acts as an indirect activator of CYP2J7 through SIRT1 activation. SIRT1 enhances the deacetylation of transcription factors, leading to increased gene expression and elevated heme binding and oxidoreductase activities, facilitating steroid hydroxylase activity and xenobiotic metabolism. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz serves as an indirect activator of CYP2J7 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J7 transcription, leading to increased expression and elevated heme binding and oxidoreductase activities, facilitating steroid hydroxylase activity and xenobiotic metabolism. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate acts as a direct activator of CYP2J7, enhancing its steroid hydroxylase activity. By activating PPARα, clofibrate promotes increased enzymatic activity, contributing to xenobiotic metabolism and organic acid metabolic processes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin serves as an indirect activator of CYP2J7 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J7 transcription, leading to increased expression and elevated heme binding and oxidoreductase activities, facilitating steroid hydroxylase activity and xenobiotic metabolism. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $33.00 $129.00 $599.00 $1647.00 | 2 | |
β-Naphthoflavone acts as a direct activator of CYP2J7, promoting the upregulation of heme binding and oxidoreductase activities. This direct interaction enhances enzymatic activity, facilitating steroid hydroxylase activity and contributing to xenobiotic metabolism and organic acid metabolic processes. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
ALA serves as an indirect activator of CYP2J7 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2J7 transcription, leading to increased expression and elevated heme binding and oxidoreductase activities, facilitating steroid hydroxylase activity and xenobiotic metabolism. | ||||||