CYP2D40 Activators
CYP2D40, belonging to the cytochrome P450 family, emerges as a critical enzyme with a predicted role in anandamide metabolism, exhibiting anandamide epoxidase activity and heme binding. This particular cytochrome P450 variant is situated within the mitochondrion, implicating its involvement in cellular processes associated with this organelle. Notably, the predicted functions of CYP2D40 extend beyond routine cytochrome P450 activities, pointing towards its unique role in mediating the metabolism of anandamide, an endocannabinoid with diverse physiological implications. The activation of CYP2D40 involves intricate cellular mechanisms orchestrated to regulate its expression and anandamide epoxidase activity. While direct activators, such as amodiaquine and clofibrate, interact with specific regulatory elements to directly upregulate anandamide epoxidase activity, indirect activators like troglitazone and sulforaphane modulate signaling pathways, namely PPARγ and Nrf2-ARE, respectively. These pathways serve as molecular switches, influencing the transcriptional machinery and coactivators that control the expression of CYP2D40. The activation of PPARα and RAR by chemicals like gemfibrozil and tretinoin, respectively, further underscores the diversity of regulatory pathways involved in modulating CYP2D40. This complex network of interactions emphasizes the multifaceted nature of CYP2D40 activation, illustrating its integration into broader cellular processes governing anandamide metabolism.
In conclusion, CYP2D40 stands as a unique member of the cytochrome P450 family, with its predicted functions in anandamide metabolism and heme binding within the mitochondrion. The intricate web of activation mechanisms involves both direct and indirect activators, showcasing the diversity of regulatory pathways that modulate the expression and activity of CYP2D40. This understanding paves the way for further exploration into the physiological significance of CYP2D40 and its potential impact on anandamide-related cellular processes. The complex regulatory network surrounding CYP2D40 activation underscores its importance in maintaining cellular homeostasis and responding to specific signaling cues within the intricate landscape of cellular biochemistry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine serves as a direct activator of CYP2D40 by binding to its regulatory elements, promoting the upregulation of anandamide epoxidase activity. This interaction triggers a cascade leading to increased enzymatic activity. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone acts as an indirect activator of CYP2D40 by modulating the PPARγ signaling pathway. Its activation of PPARγ enhances the transcription of CYP2D40, leading to increased expression and subsequent enzymatic activation. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine serves as a CYP2D40 activator by influencing the L-type calcium channel signaling pathway. Calcium influx activates transcription factors, resulting in increased gene expression and heightened anandamide epoxidase activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane acts as an indirect activator of CYP2D40 through its modulation of the Nrf2-ARE pathway. Activation of Nrf2 enhances CYP2D40 transcription, leading to increased expression and subsequent elevation of anandamide epoxidase activity. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate serves as a direct activator of CYP2D40 by activating PPARα, which binds to the gene promoter region, enhancing anandamide epoxidase activity. This direct interaction leads to increased transcription and heightened enzymatic function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA acts as an indirect activator of CYP2D40 by activating protein kinase C (PKC). PKC activation leads to downstream signaling events, ultimately enhancing the expression of CYP2D40 and promoting increased anandamide epoxidase activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol serves as an indirect activator of CYP2D40 through SIRT1 activation. SIRT1 enhances the deacetylation of transcription factors, leading to increased gene expression and elevated anandamide epoxidase activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone acts as a direct activator of CYP2D40 by modulating glucocorticoid receptor signaling. This interaction enhances the transcription of CYP2D40, leading to increased expression and subsequent elevation of anandamide epoxidase activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate serves as an indirect activator of CYP2D40 by influencing the Wnt/β-catenin signaling pathway. Activation of this pathway enhances CYP2D40 transcription, leading to increased expression and elevated anandamide epoxidase activity. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil acts as a direct activator of CYP2D40 by activating PPARα, which binds to the gene promoter region, enhancing anandamide epoxidase activity. This direct interaction leads to increased transcription and heightened enzymatic function. | ||||||