Cyp2c39 Activators
Cyp2c39, a member of the cytochrome P450 family, is a key player in arachidonic acid metabolism, specifically as an arachidonic acid 11,12-epoxygenase. Located in the endoplasmic reticulum and membrane-bound organelles, it exhibits crucial activities in the cytoplasm and intracellular membrane-bounded organelles. The gene is implicated in various diseases, including Plasmodium falciparum malaria, eosinophilic esophagitis, glucose metabolism diseases, invasive aspergillosis, and multiple chemical sensitivity.
Activation of Cyp2c39 involves a complex interplay of signaling pathways influenced by various chemicals. Clofibrate and Fenofibrate act as direct activators, enhancing the enzyme's 11,12-epoxygenase activity and modulating lipid metabolism. AUDA and Resveratrol directly activate Cyp2c39 by preserving epoxyeicosatrienoic acids (EETs), contributing to vasodilation and anti-inflammatory effects. Indirect activators like GW7647, Troglitazone, and WY-14643 influence PPAR agonists, upregulating Cyp2c39 expression and enhancing its arachidonic acid 11,12-epoxygenase activity. Quercetin and Zileuton indirectly activate Cyp2c39 by inhibiting LOX and 5-LOX, respectively, promoting the redirection of arachidonic acid towards epoxygenase pathways. Montelukast and Losartan indirectly activate Cyp2c39 by influencing arachidonic acid metabolism, enhancing EETs synthesis. Ibuprofen indirectly activates Cyp2c39 by inhibiting COX enzymes, redirecting arachidonic acid towards epoxygenase pathways. Overall, these chemicals highlight the intricate network of pathways influencing Cyp2c39 activation, providing insights into potential strategies for modulating arachidonic acid metabolism and related diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647, a peroxisome proliferator-activated receptor alpha (PPARα) agonist, serves as an indirect activator of Cyp2c39. By activating PPARα, it upregulates the expression of Cyp2c39, enhancing its arachidonic acid 11,12-epoxygenase activity and contributing to the modulation of eicosanoid synthesis and lipid metabolism. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone, a PPARγ agonist, indirectly activates Cyp2c39 by modulating arachidonic acid metabolism. By activating PPARγ, it upregulates the expression of Cyp2c39, enhancing its epoxygenase activity and contributing to the regulation of eicosanoid synthesis and lipid metabolism. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate, a fibric acid derivative, acts as a direct activator of Cyp2c39. By directly influencing arachidonic acid metabolism, it enhances the enzyme's 11,12-epoxygenase activity, leading to increased production of biologically active eicosanoids and the modulation of lipid metabolism. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
WY-14643, a PPARα agonist, indirectly activates Cyp2c39 by activating PPARα, upregulating the expression of Cyp2c39. This enhances the enzyme's 11,12-epoxygenase activity, contributing to the modulation of arachidonic acid metabolism and the synthesis of biologically active eicosanoids. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, indirectly activates Cyp2c39 by influencing arachidonic acid metabolism. It inhibits lipoxygenase (LOX) enzymes, redirecting arachidonic acid towards Cyp2c39-mediated epoxygenase pathways, leading to enhanced synthesis of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenol, serves as an indirect activator of Cyp2c39. By activating sirtuin 1 (SIRT1), it upregulates the expression of Cyp2c39, enhancing its 11,12-epoxygenase activity and contributing to the modulation of arachidonic acid metabolism and the synthesis of biologically active eicosanoids. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan, an angiotensin II receptor antagonist, indirectly activates Cyp2c39 by modulating arachidonic acid metabolism. By blocking the effects of angiotensin II, it promotes the redirection of arachidonic acid towards Cyp2c39-mediated epoxygenase pathways, enhancing the synthesis of epoxyeicosatrienoic acids (EETs). | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton, a 5-lipoxygenase (5-LOX) inhibitor, indirectly activates Cyp2c39 by influencing arachidonic acid metabolism. By blocking the effects of 5-LOX, it promotes the redirection of arachidonic acid towards Cyp2c39-mediated epoxygenase pathways, leading to increased synthesis of epoxyeicosatrienoic acids (EETs) with anti-inflammatory properties. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate, a fibric acid derivative, acts as a direct activator of Cyp2c39. By directly influencing arachidonic acid metabolism, it enhances the enzyme's 11,12-epoxygenase activity, leading to increased production of biologically active eicosanoids and the modulation of lipid metabolism. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), indirectly activates Cyp2c39 by modulating arachidonic acid metabolism. It inhibits cyclooxygenase (COX) enzymes, redirecting arachidonic acid towards Cyp2c39-mediated epoxygenase pathways, leading to enhanced synthesis of epoxyeicosatrienoic acids (EETs) with anti-inflammatory properties. | ||||||