Date published: 2025-10-6

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cyclin D1 Inhibitors

Cyclin D1 inhibitors belong to a specific chemical class of compounds that primarily interact with and modulate the activity of cyclin D1, a key protein involved in cell cycle progression. Cyclin D1 is a regulatory protein that plays a critical role in the transition from the G1 phase to the S phase of the cell cycle. This transition is a crucial step in the cell division process, where the cell prepares for DNA replication and subsequent division. Cyclin D1 forms complexes with cyclin-dependent kinases (CDKs), which together regulate the phosphorylation of key substrates, enabling cell cycle progression. The inhibitors targeting cyclin D1 function by disrupting the formation or activity of cyclin D1-CDK complexes. By doing so, they interfere with the proper phosphorylation of downstream targets involved in the cell cycle machinery. These inhibitors are designed to specifically bind to cyclin D1 or its associated CDKs, thereby preventing the normal interaction between cyclin D1 and CDKs. This disruption halts the progression of the cell cycle from the G1 to the S phase, leading to a pause in cell division. The intricate control of cell cycle progression is essential for maintaining genomic integrity and proper cellular growth, making cyclin D1 inhibitors valuable tools for research aimed at understanding cellular processes. In summary, cyclin D1 inhibitors constitute a distinctive class of compounds that intricately interfere with the activity of cyclin D1, a vital player in the regulation of cell cycle progression. Through their targeted disruption of cyclin D1-CDK interactions, these inhibitors contribute to the modulation of key signaling pathways governing cell division. This nuanced interference at the molecular level underscores their significance in elucidating fundamental cellular mechanisms.

Items 1 to 10 of 16 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Fascaplysin

114719-57-2sc-221607
sc-221607A
1 mg
5 mg
$63.00
$241.00
5
(1)

Fascaplysin (CAS 114719-57-2) is a chemical compound derived from marine sources. It functions as an inhibitor of cyclin D1, a key regulator of the cell cycle. By targeting cyclin D1, fascaplysin modulates cell cycle progression and has been studied for its potential impacts on cellular processes.

SU 9516

377090-84-1sc-222330
sc-222330A
5 mg
25 mg
$122.00
$383.00
3
(1)

SU 9516 (CAS 377090-84-1) is a chemical inhibitor targeting cyclin D1, a key protein involved in cell cycle regulation. It modulates cyclin D1 function, impacting cellular processes linked to growth and proliferation.

Indirubin

479-41-4sc-201531
sc-201531A
5 mg
25 mg
$112.00
$515.00
4
(1)

Indirubin (CAS 479-41-4) is a natural chemical compound known for its ability to inhibit cyclin D1, a key regulator of the cell cycle. By interfering with cyclin D1 function, indirubin modulates cellular processes related to growth and division. Its unique mechanism of action holds potential implications in various biological contexts.

Cdk4 Inhibitor Inhibitor

546102-60-7sc-203873
1 mg
$134.00
5
(1)

Cdk4 Inhibitor (CAS 546102-60-7) is a chemical substance recognized for its ability to modulate the activity of cyclin D1, a key regulatory protein in the cell cycle. By interacting with cyclin D1, this inhibitor influences the intricate process of cell division.

Abemaciclib

1231929-97-7sc-507342
10 mg
$110.00
(0)

Another approved CDK4/6 inhibitor that effectively inhibits cyclin D1-associated cell cycle progression. It is used in the research of various advanced or metastatic cancers.

Indirubin-5-sulfonic acid sodium salt

sc-221755
sc-221755A
1 mg
5 mg
$57.00
$324.00
(0)

Indirubin-5-sulfonic acid sodium salt is a recognized chemical compound that functions as a selective inhibitor of cyclin D1, a crucial protein in cell cycle progression. By targeting cyclin D1, it modulates cell division processes. Its inhibitory action on cyclin D1 underscores its significance in cellular growth and proliferation control.

Ribociclib

1211441-98-3sc-507367
10 mg
$450.00
(0)

Similar to palbociclib and abemaciclib, this CDK4/6 inhibitor disrupts cyclin D1-mediated cell cycle regulation and is employed for specific types of breast cancer.

Oxindole I

sc-222104
10 mg
$273.00
2
(0)

Oxindole I is a chemical compound that exerts its effects as an inhibitor of cyclin D1, a crucial protein involved in regulating the cell cycle. By targeting cyclin D1, Oxindole I modulates the progression of the cell cycle, impacting cellular growth and division. This interaction plays a significant role in cellular processes and has garnered attention for its potential implications in various biological contexts.

Arcyriaflavin A

118458-54-1sc-202470
sc-202470A
sc-202470B
1 mg
10 mg
100 mg
$152.00
$292.00
$1796.00
4
(2)

Arcyriaflavin A (CAS 118458-54-1) is a potent inhibitor of cyclin D1, a critical regulator of the cell cycle. By targeting cyclin D1, it modulates cell cycle progression and influences cellular proliferation. This compound's interaction with cyclin D1 highlights its potential role in regulating cell division processes.

NSC 625987

141992-47-4sc-203653
10 mg
$159.00
(0)

NSC 625987 (CAS 141992-47-4) is a chemical compound recognized for its role as a potent inhibitor of cyclin D1. By specifically targeting cyclin D1, it modulates crucial processes in cellular cycle regulation.