Molecular structure of NSC 625987, CAS Number: 141992-47-4
NSC 625987 (CAS 141992-47-4)
Alternate Names:
1,4-Dimethoxy-9(10H)-acridinethione
Application:
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor
CAS Number:
141992-47-4
Purity:
≥95%
Molecular Weight:
271.33
Molecular Formula:
C15H13NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 µM at cdk4/cyclin D1). It displays > 500-fold selectivity over cdk2 (IC50 > 100 µM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
NSC 625987 (CAS 141992-47-4) References
Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279. McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competitInhibitor of:
APC13, Cdk4, cyclin D1, p21, PITSLRE A, TTC14, and ZDHHC24.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NSC 625987, 10 mg | sc-203653 | 10 mg | $159.00 |