Molecular structure of SU 9516, CAS Number: 377090-84-1
SU 9516 (CAS 377090-84-1)
See product citations (3)
Alternate Names:
3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
Application:
SU 9516 is a cell permeable, potent, selective and ATP-competitive inhibitor
CAS Number:
377090-84-1
Molecular Weight:
241.25
Molecular Formula:
C13H11N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU 9516 is a cell permeable, potent, selective and ATP-competitive inhibitor of Cdk2/cyclin A (IC50=22nM), Cdk1/cyclin B (IC50=40nM) and Cdk4/cyclin D1 (IC50=200nM). SU9516 has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10μM). The compound displays anti-proliferative and pro-apoptotic properties in tumor cells and inhibits proliferation of growth factor-stimulated colon carcinoma cells. SU 9516 does this by binding to Cdk2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
SU 9516 (CAS 377090-84-1) References
M.E. Lane, et al.; Cancer Res. 61, 6170 (2001). B. Yu, et al.; Biochem Pharmacol. 64, 1091 (2002). D.J. Moshinsky, et al.; BBRC 310, 1026 (2003). X. Li, et al.; Bioorg. Med. Chem. Lett. 13, 1939 (2003).Inhibitor of:
CCNI2, Cdk1, Cdk2, Cdk4, CINP, Clb3, CLK2, cyclin A, cyclin B, cyclin D1, cyclin E, DOC1, Inv, Myt 1, PBK, PCTAIRE-3, Pho85, PLEKHA6, rotatin, RPRD2, and ZHX3.Activator of:
Cables1, and SOLO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 9516, 5 mg | sc-222330 | 5 mg | $124.00 | |||
SU 9516, 25 mg | sc-222330A | 25 mg | $391.00 |