Date published: 2026-5-30

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Cya A Inhibitors

CyaA inhibitors, also known as adenylate cyclase toxin inhibitors, are a class of chemical compounds designed to target and inhibit the activity of the bacterial toxin called CyaA (Cyclic AMP-activated toxin). CyaA is a virulence factor produced by certain pathogenic bacteria, most notably by Bordetella pertussis, the causative agent of whooping cough. This toxin plays a crucial role in the pathogenicity of these bacteria by disrupting the host's immune response. CyaA inhibitors are developed to counteract this bacterial virulence mechanism and provide a means of controlling bacterial infections. CyaA, once secreted by the bacteria, binds to the host cell membrane and inserts itself into the cell membrane. It then catalyzes the conversion of ATP (adenosine triphosphate) into cyclic AMP (cAMP), a secondary messenger molecule in cells. Elevated levels of cAMP disrupt the normal signaling pathways in the host immune cells, leading to immune suppression and evasion. CyaA inhibitors are designed to interfere with the enzymatic activity of CyaA, preventing it from converting ATP to cAMP. This inhibition effectively neutralizes the toxin's ability to disrupt host cell signaling and immune function, aiding in the control of bacterial infections by allowing the host's immune system to mount a more effective defense against the invading pathogen. Researchers continue to investigate and develop CyaA inhibitors as a strategy to combat bacterial infections that rely on this virulence factor for their pathogenicity.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rifampicin

13292-46-1sc-200910
sc-200910A
sc-200910B
sc-200910C
1 g
5 g
100 g
250 g
$97.00
$328.00
$676.00
$1467.00
6
(1)

Rifampicin can bind to the bacterial RNA polymerase, inhibiting the initiation of RNA synthesis. This can lead to a reduction in the transcription of virulence factors, including Cya A.

Chloramphenicol

56-75-7sc-3594
25 g
$90.00
10
(1)

Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This action can prevent the synthesis of Cya A and other proteins essential for bacterial survival and virulence.

Tetracycline

60-54-8sc-205858
sc-205858A
sc-205858B
sc-205858C
sc-205858D
10 g
25 g
100 g
500 g
1 kg
$63.00
$94.00
$270.00
$417.00
$634.00
6
(1)

Tetracycline binds to the 30S ribosomal subunit, inhibiting protein synthesis in bacteria. This can lead to a decrease in the expression of Cya A and other proteins involved in bacterial virulence.

Kanamycin

8063-07-8sc-492406
1 g
$500.00
3
(0)

Kanamycin Sulfate interferes with bacterial protein synthesis by binding to the 30S ribosomal subunit. This can result in a reduction in Cya A expression and impair the virulence of Bordetella pertussis.

Ciprofloxacin

85721-33-1sc-217900
1 g
$43.00
8
(1)

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and transcription. This action can lead to a decrease in the transcription and expression of Cya A and other virulence factors.

Ethambutol

74-55-5sc-205684
sc-205684A
25 g
100 g
$412.00
$1161.00
1
(1)

Ethambutol inhibits the synthesis of arabinogalactan, a crucial component of the mycobacterial cell wall. While its primary action is against Mycobacterium species, it may also have indirect effects on the expression of virulence factors like Cya A in other bacterial pathogens.

Streptomycin sulfate

3810-74-0sc-202821
sc-202821A
10 g
100 g
$92.00
$131.00
12
(1)

Streptomycin sulfate binds to the 30S ribosomal subunit, causing misreading of mRNA and inhibiting protein synthesis. This can lead to a reduction in the synthesis of Cya A and other proteins, impacting bacterial virulence.

Fosfomycin Disodium Salt

26016-99-9sc-211542
sc-211542A
1 g
5 g
$40.00
$104.00
(1)

Fosfomycin Disodium Salt inhibits the bacterial enzyme MurA, disrupting the synthesis of peptidoglycan precursors and weakening the bacterial cell wall. This can indirectly affect the expression of virulence factors like Cya A.

Gentamicin sulfate

1405-41-0sc-203334
sc-203334A
sc-203334F
sc-203334B
sc-203334C
sc-203334D
sc-203334E
1 g
5 g
50 g
100 g
1 kg
2.5 kg
7.5 kg
$56.00
$179.00
$509.00
$725.00
$1836.00
$2652.00
$6248.00
3
(1)

Gentamycin binds to the 30S ribosomal subunit, inhibiting protein synthesis and potentially leading to a decrease in the expression of Cya A and other virulence factors in Bordetella pertussis.

Azithromycin

83905-01-5sc-254949
sc-254949A
sc-254949B
sc-254949C
sc-254949D
25 mg
50 mg
500 mg
1 g
5 g
$52.00
$103.00
$260.00
$364.00
$728.00
17
(1)

Azithromycin binds to the 50S ribosomal subunit, inhibiting protein synthesis in bacteria. This action can lead to a reduction in the expression of Cya A and other proteins critical for bacterial virulence.