Kanamycin (CAS 8063-07-8)
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Kanamycin is an aminoglycoside antibiotic. The antibiotic spectrum of Kanamycin encompasses both Gram-positive and Gram-negative bacteria, targeting pathogens like Escherichia coli, Salmonella, and Pseudomonas aeruginosa. In laboratory experiments, it serves to select bacterial mutants and investigate gene expression and regulation mechanisms. It contributes to the investigation of bacterial physiology, encompassing protein synthesis regulation and the impact of antibiotics on bacterial metabolism. It also finds utility in investigating gene expression and regulation in mammalian cells, as well as assessing the effects of antibiotics on cells. Kanamycin impedes protein production within bacterial cells. By binding to the 30S ribosomal subunit, it obstructs the formation of a functional 70S ribosome. Consequently, bacterial protein synthesis is disrupted, leading to the inhibition of bacterial growth.
Kanamycin (CAS 8063-07-8) References
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- Cross-resistance of Mycobacterium tuberculosis isolates among streptomycin, kanamycin and amikacin. | Sugawara, I., et al. 2009. Indian J Exp Biol. 47: 520-2. PMID: 19634718
- Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation. | Park, JW., et al. 2011. Nat Chem Biol. 7: 843-52. PMID: 21983602
- Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups. | Salian, S., et al. 2012. Antimicrob Agents Chemother. 56: 6104-8. PMID: 22948879
- Design, synthesis, and antibacterial activities of conformationally constrained kanamycin A derivatives. | Zhang, W., et al. 2013. J Org Chem. 78: 400-9. PMID: 23228010
- Amikacin, kanamycin and tobramycin binding to melanin in the presence of Ca(2+) and Mg(2+) ions. | Wrześniok, D., et al. 2012. Acta Pol Pharm. 69: 1035-41. PMID: 23285663
- Direct electrochemical detection of kanamycin based on peroxidase-like activity of gold nanoparticles. | Wang, C., et al. 2016. Anal Chim Acta. 936: 75-82. PMID: 27566341
- How kanamycin A interacts with bacterial and mammalian mimetic membranes. | John, T., et al. 2017. Biochim Biophys Acta Biomembr. 1859: 2242-2252. PMID: 28847502
- Click chemistry inspired copper sulphide nanoparticle-based fluorescence assay of kanamycin using DNA aptamer. | Belal, ASF., et al. 2018. Spectrochim Acta A Mol Biomol Spectrosc. 205: 48-54. PMID: 30007899
- Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis. | Kudo, F., et al. 2020. Biochemistry. 59: 1470-1473. PMID: 32237736
- Development of label-free fluorescent biosensor for the detection of kanamycin based on aptamer capped metal-organic framework. | Liu, S., et al. 2022. Environ Res. 206: 112617. PMID: 34968433
- Comparative ototoxicity of kanamycin A and kanamycin B in the guinea pig. | Yung, MW. 1987. Acta Otolaryngol. 103: 73-80. PMID: 3564930
- Interaction of kanamycin A and kanamycin B with phospholipids. | Yung, MW. and Green, C. 1987. J Antibiot (Tokyo). 40: 862-7. PMID: 3610836
- Deglycosylation Inactivation Initiated by a Novel Periplasmic Dehydrogenase Complex Provides a Novel Strategy for Eliminating the Recalcitrant Antibiotic Kanamycin. | Chen, Z., et al. 2023. Environ Sci Technol. 57: 4298-4307. PMID: 36857046
- Concentrations of kanamycin and amikacin in human gallbladder bile and wall. | Hansbrough, JF., et al. 1981. Antimicrob Agents Chemother. 20: 515-7. PMID: 7342877
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kanamycin, 1 g | sc-492406 | 1 g | $500.00 |