Molecular structure of Ethambutol, CAS Number: 74-55-5
Ethambutol (CAS 74-55-5)
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Alternate Names:
Myambutol; Tibutol
Application:
Ethambutol is an antitubercular antibiotic
CAS Number:
74-55-5
Purity:
≥98%
Molecular Weight:
204.31
Molecular Formula:
C10H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ethambutol is an efficient antibiotic with bacteriostatic, antimicrobial, and antitubercular properties. It disrupts the synthesis of arabinogalactan, a key polysaccharide in the mycobacterial cell wall, by blocking arabinosyl transferases. This inhibits the polymerization of cell wall arabinan and lipoarabinomannan, leading to the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. Consequently, bacterial growth is halted as a result of inhibited cell wall complex production and increased permeability.
Ethambutol (CAS 74-55-5) References
- Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy. | Zimmerman, M., et al. 2017. Antimicrob Agents Chemother. 61: PMID: 28696241
- New insights on Ethambutol Targets in Mycobacterium tuberculosis. | Ghiraldi-Lopes, LD., et al. 2019. Infect Disord Drug Targets. 19: 73-80. PMID: 29366429
- Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study. | Mehta, K., et al. 2019. J Antimicrob Chemother. 74: 2994-3002. PMID: 31273386
- Role of ethambutol and rifampicin in the treatment of Mycobacterium avium complex pulmonary disease. | Kim, HJ., et al. 2019. BMC Pulm Med. 19: 212. PMID: 31711459
- Pupillary light reflex in ethambutol-induced optic neuropathy. | Yoo, YJ., et al. 2020. Sci Rep. 10: 21601. PMID: 33303779
- Ethambutol Induced Lichenoid Drug Eruption: A Case Report. | Yuyaem, T., et al. 2021. Curr Drug Saf. 16: 296-298. PMID: 33334297
- Ethambutol Optic Neuropathy: Vigilance and Screening, the Keys to Prevent Blindness with the Revised Anti-tuberculous Therapy Regimen. | Saxena, R., et al. 2021. J Assoc Physicians India. 69: 54-57. PMID: 33527812
- Efficacy of Fluoroquinolones as Substitutes for Ethambutol or Rifampin in the Treatment of Mycobacterium avium Complex Pulmonary Disease According to Radiologic Types. | Lee, JH., et al. 2022. Antimicrob Agents Chemother. 66: e0152221. PMID: 34930036
- Low-dosage ethambutol, less than 12.5 mg/kg/day, does not worsen the clinical outcomes of pulmonary Mycobacterium avium and Mycobacterium intracellulare disease: a retrospective cohort study. | Watanabe, F., et al. 2022. Infection. 50: 879-887. PMID: 35106717
- Relationship between Resistance to Ethambutol and Rifampin and Clinical Outcomes in Mycobacterium avium Complex Pulmonary Disease. | Moon, SM., et al. 2022. Antimicrob Agents Chemother. 66: e0202721. PMID: 35266825
- Ethambutol-induced bullous skin lesions in mycobacterium kansasii lung infection. | Kollipara, VK., et al. 2022. Int J Mycobacteriol. 11: 120-122. PMID: 35295035
- Population pharmacokinetics of ethambutol in African children: a pooled analysis. | Tikiso, T., et al. 2022. J Antimicrob Chemother. 77: 1949-1959. PMID: 35466379
- The Effect of Citicoline on Ethambutol Optic Neuropathy: Histopathology and Immunohistochemistry Analysis of Retina Ganglion Cell Damage Level in Rat Model. | Nusanti, S., et al. 2022. J Ocul Pharmacol Ther. 38: 584-589. PMID: 36074092
- mbtD and celA1 association with ethambutol resistance in Mycobacterium tuberculosis: A multiomics analysis. | Wu, Z., et al. 2022. Front Cell Infect Microbiol. 12: 959911. PMID: 36118032
- Activities of antimicrobial agents against clinical isolates of Mycobacterium haemophilum. | Bernard, EM., et al. 1993. Antimicrob Agents Chemother. 37: 2323-6. PMID: 8285613
Inhibitor of:
Brucella abortus LPS, LYRM7, Mycobacterium avium, OPN1LW, Penicillin, Rhodopsin, RmlB, RV2623 Dormancy Regulon, RV3134 Dormancy Regulon, and Sigma 54.Activator of:
Ag85, ESAT6, and MT 38 kDa antigen.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ethambutol, 25 g | sc-205684 | 25 g | $404.00 | |||
Ethambutol, 100 g | sc-205684A | 100 g | $1138.00 |