CXorf58 Activators
CXorf58 activators encompass a diverse array of compounds that manipulate intracellular signaling cascades, culminating in the upregulation of this protein's activity. Certain activators work by increasing the levels of cyclic adenosine monophosphate (cAMP) within the cell, either through direct stimulation of adenylyl cyclase or by inhibiting the enzymes responsible for cAMP degradation. The elevated cAMP activates protein kinase A, a kinase that can phosphorylate a variety of substrates, potentially including CXorf58. This phosphorylation can lead to a change in the protein's conformation, enabling it to perform its cellular functions more effectively. Other activators operate through alternative pathways, such as the activation of protein kinase C, which might also target CXorf58 for phosphorylation. Additionally, the intracellular concentration of calcium ions can be manipulated to activate calcium-sensitive kinases, which can then phosphorylate and activate CXorf58, thereby amplifying its functional activity within the cell.
Moreover, CXorf58 activity can be modulated through the nitric oxide signaling pathway. Compounds that serve as nitric oxide donors or that augment cGMP levels can activate protein kinase G, another kinase that may target CXorf58 for phosphorylation. This mechanism underscores the intricate balance of enzymatic reactions that govern cellular signaling and the cascading effects that can result in the activation of specific proteins. In the context of CXorf58, these activation mechanisms demonstrate the sophisticated interplay of second messengers and protein kinases, which are central to the regulation of its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective phosphodiesterase inhibitor that prevents cAMP degradation, thereby potentiating the signaling cascade that can lead to phosphorylation and activation of CXorf58 by protein kinase A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C (PKC) which may phosphorylate and activate CXorf58 if it is a substrate for this kinase. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol found in green tea known to influence multiple intracellular signaling pathways including the activation of AMP-activated protein kinase (AMPK). Activation of AMPK could lead to the phosphorylation and activation of CXorf58. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
A substrate for nitric oxide synthase, resulting in the production of nitric oxide (NO) which can activate guanylate cyclase, increasing cGMP levels. This can enhance the activity of protein kinase G (PKG), which may phosphorylate and activate CXorf58. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
A nitric oxide donor which can activate guanylate cyclase, leading to increased cGMP and activation of PKG that may phosphorylate and activate CXorf58. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
An ionophore that increases intracellular calcium concentration, potentially activating calmodulin-dependent kinases (CaMK) which could phosphorylate and activate CXorf58. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that activates adenylyl cyclase, increasing cAMP levels, and subsequently activating PKA which could lead to the phosphorylation and activation of CXorf58. | ||||||
S-Nitrosoglutathione (GSNO) | 57564-91-7 | sc-200349 sc-200349B sc-200349A sc-200349C | 10 mg 25 mg 50 mg 100 mg | $85.00 $206.00 $339.00 $449.00 | 15 | |
A nitric oxide donor that can lead to the activation of guanylate cyclase, increasing cGMP levels and potentially activating PKG which could phosphorylate and activate CXorf58. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
A selective inhibitor of phosphodiesterase 5 (PDE5) which prevents the degradation of cGMP, potentially enhancing PKG activity and leading to the phosphorylation and activation of CXorf58. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of phosphodiesterase 4 (PDE4) which enhances cAMP levels, potentially leading to PKA activation and the subsequent phosphorylation and activation of CXorf58. | ||||||