CUL-3 Activators
Cullin-3 (CUL-3) is an essential component of the cullin-RING ligase (CRL) family, which plays pivotal roles in cellular protein ubiquitination and degradation. Ubiquitination, in this context, refers to the process by which target proteins are labeled with ubiquitin molecules, signaling them for degradation by the proteasome, a cellular machine responsible for breaking down and recycling proteins. The CRL complex, where CUL-3 is a key member, acts as a scaffold that brings together several other proteins and facilitates the ubiquitination of specific target proteins. In this intricate process, CUL-3 binds to a RING protein and a substrate-specific adaptor protein, ensuring the correct target proteins are ubiquitinated. Activators of CUL-3, therefore, are chemicals or molecules that enhance or promote the activity of the CUL-3 protein, potentially influencing the rate or specificity of protein ubiquitination.
The precise mechanism of CUL-3 activators remains a subject of investigation, but it is generally believed that these activators could either directly enhance CUL-3's binding affinity with its partners or modulate its conformation to be more conducive for efficient ubiquitination. The balance of protein ubiquitination is crucial for cellular health and homeostasis. When this balance is skewed, either due to reduced or excessive ubiquitination, it can lead to a variety of cellular malfunctions or dysregulations. Therefore, understanding CUL-3 activators, their structures, and modes of action is not only crucial for elucidating cellular protein regulation but also for potentially providing insights into larger biological systems and processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, may enhance the expression of CUL-3 by activating the Nrf2 signaling pathway, leading to increased cellular defense against oxidative stress and potentially aiding in the maintenance of cellular homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenol in turmeric, could upregulate CUL-3 expression through its anti-inflammatory and antioxidant properties, possibly contributing to the regulation of cellular processes and stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, present in grapes and red wine, may influence CUL-3 expression by modulating signaling pathways related to longevity and stress resistance, potentially aiding in the protection of cells from damage. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid in various fruits and vegetables, might increase CUL-3 expression through its antioxidant activity, helping to maintain cellular health and mitigate the effects of oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, could enhance CUL-3 expression, potentially playing a role in cellular defense mechanisms against oxidative stress and contributing to the regulation of cell cycle and apoptosis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, may upregulate CUL-3 expression, potentially contributing to cellular differentiation and development processes, as well as the maintenance of cellular homeostasis. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 may influence CUL-3 expression, possibly playing a role in calcium homeostasis, immune function, and cellular differentiation, and aiding in the maintenance of overall cellular health. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyrate, a short-chain fatty acid produced by gut microbiota, could increase CUL-3 expression, potentially contributing to the regulation of inflammation, enhancement of gut barrier function, and maintenance of cellular health. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may modulate CUL-3 expression, potentially influencing cellular signaling pathways involved in mood regulation and neuroprotection, and playing a role in cellular responses to stress. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $48.00 $179.00 $310.00 $96.00 | 3 | |
Sodium selenite, a form of selenium, could enhance CUL-3 expression, potentially playing a role in cellular defense against oxidative stress, contributing to the maintenance of cellular homeostasis, and aiding in the detoxification of harmful substances. | ||||||