CUL-1 Inhibitors
CUL-1 inhibitors are a class of small molecules or compounds that target the Cullin-1 protein, a key component of the Cullin-RING E3 ubiquitin ligase (CRL) complex. The CUL-1 protein plays a critical role in the regulation of protein degradation within cells through the ubiquitin-proteasome system. This system is responsible for tagging specific proteins for degradation, allowing the cell to maintain protein homeostasis and control the levels of various signaling molecules and regulatory proteins. Inhibition of CUL-1 can disrupt the normal function of the CRL complex, leading to the stabilization of target proteins that would otherwise be degraded. This modulation of protein levels can have profound effects on cellular processes, including cell cycle regulation, DNA repair, and signal transduction.
CUL-1 inhibitors are valuable tools in the field of cell biology and molecular research, as they enable scientists to dissect the roles of specific proteins within cellular pathways. By selectively blocking the activity of CUL-1, researchers can investigate the downstream consequences of protein stabilization, shedding light on the functions of the targeted proteins and their involvement in disease processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin directly binds to FKBP12, and the complex formed inhibits the mammalian target of rapamycin (mTOR), a serine/threonine kinase that plays a central role in regulating cell growth and survival. Inhibition of mTOR can lead to decreased protein synthesis, impacting the expression of numerous proteins, potentially including CUL-1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, found in various fruits and vegetables. It modulates several signaling pathways and can affect the expression of various proteins, potentially including CUL-1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soybeans. It acts as a phytoestrogen and has been shown to modulate various signaling pathways, potentially impacting the expression of proteins, including CUL-1. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes. In addition to its well-known effects on pain and inflammation, aspirin has been shown to modulate various signaling pathways and transcription factors, potentially influencing the expression of proteins such as CUL-1. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine is an antimalarial drug that also has anti-inflammatory properties. It modulates lysosomal function and immune system activity, potentially affecting the expression of various proteins, including CUL-1. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is an inhibitor of autophagy, a cellular degradation process. By inhibiting autophagy, 3-methyladenine can influence the turnover and expression of various proteins, potentially including CUL-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), which plays a key role in various cellular processes including cell survival and growth. Inhibition of PI3K can lead to changes in protein expression, potentially impacting CUL-1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. Similar to LY294002, its inhibition of PI3K activity can lead to alterations in cell survival, growth, and protein expression, potentially affecting the expression of CUL-1. | ||||||