CTBS Inhibitors
CTBS inhibitors, classified by their influence on related cellular pathways, primarily target the processes of RNA synthesis, RNA modification, and protein translation. Agents like Actinomycin D, α-Amanitin, DRB, and Ribavirin hinder RNA synthesis by distinct mechanisms. For instance, Actinomycin D binds specifically to guanosine-cytosine rich DNA sequences, inhibiting RNA synthesis, while α-Amanitin selectively obstructs RNA polymerase II. The reduced synthesis of RNA can indirectly impede CTBS's RNA modification activity, given that it operates within this cellular context.
Additionally, compounds such as 5-Azacytidine and Mycophenolic acid can influence gene expression and RNA synthesis, respectively. By doing so, they have potential implications for CTBS's functional role in RNA modification. Compounds affecting protein translation, including Puromycin, Cycloheximide, and Rapamycin, exert their effects on ribosomal function or broader translation regulatory pathways. Given that CTBS's role intertwines with RNA processes that are precursors to protein translation, altering translation dynamics can indirectly influence CTBS. Lastly, inhibitors of glycolysis and cellular energy pathways, such as 2-Deoxyglucose and Oxamate, provide an indirect avenue to modulate CTBS. Disturbances in cellular energetics can have cascading effects on enzymatic functions, including those related to RNA, where CTBS operates.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to the guanosine-cytosine rich regions of DNA and inhibits RNA synthesis. By disrupting RNA synthesis, it can indirectly affect CTBS function related to RNA modification. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
RNA polymerase II inhibitor that prevents mRNA synthesis. A reduction in mRNA synthesis can indirectly affect CTBS function by reducing the substrate availability. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor, altering gene expression patterns. By affecting gene expression, CTBS activity related to RNA modification might be modulated. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibitor of RNA polymerase II, reducing RNA synthesis. CTBS, being involved in RNA modification, can have altered function when RNA synthesis is affected. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Guanosine analog that inhibits RNA-dependent RNA polymerase. This can lead to altered RNA synthesis and modification, potentially affecting CTBS function. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase leading to a decrease in guanosine synthesis. This can indirectly affect CTBS's role in RNA modification due to altered RNA synthesis. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Causes premature chain termination during translation. With altered protein synthesis, CTBS's function related to RNA modification can be indirectly influenced. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Glycolysis inhibitor. Cellular energy imbalance and reduced ATP production can indirectly modulate the function of enzymes like CTBS involved in RNA processes. | ||||||
Sodium oxamate | 565-73-1 | sc-215880 sc-215880B sc-215880C sc-215880D sc-215880A | 5 g 100 g 250 g 1 kg 25 g | $77.00 $469.00 $1106.00 $4111.00 $152.00 | 14 | |
LDH inhibitor, affecting pyruvate to lactate conversion in glycolysis. By influencing energy pathways, CTBS function in RNA modification might be affected indirectly. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits the translation process by affecting the ribosome's peptide transfer step. Reduced protein synthesis can indirectly modulate CTBS function in RNA modification. | ||||||