CTBS Activators
CTBS activators are compounds that can modulate the lysosomal environment or processes that indirectly impact CTBS's enzymatic activity. Compounds such as chloroquine and NH4Cl alter lysosomal pH, which is crucial for the optimal activity of lysosomal enzymes like CTBS. By maintaining a less acidic pH, these compounds can increase the activity of acid hydrolases, including CTBS, within the lysosome.
Additionally, lysosomotropic agents like methylamine and inhibitors of lysosomal proteases, such as E-64d and leupeptin, can lead to the buildup of undegraded materials, potentially triggering a compensatory increase in CTBS expression and activity. Ionophores like monensin and autophagy-modulating agents such as 3-methyladenine and lithium chloride can also impact lysosomal enzyme levels, contributing to enhanced CTBS activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ammonium Chloride | 12125-02-9 | sc-202936 sc-202936A sc-202936B | 25 g 500 g 2.5 kg | $39.00 $55.00 $150.00 | 4 | |
It acts as a lysosomotropic agent which can lead to an increase in lysosomal pH, potentially enhancing the enzymatic activity of CTBS by creating a favorable pH environment. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
A cysteine protease inhibitor that can lead to the accumulation of substrates within lysosomes, possibly inducing a compensatory upregulation of lysosomal enzymes including CTBS to deal with the increased load. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
A specific inhibitor of the vacuolar type H+-ATPase that can disrupt normal acidification of lysosomes and possibly induce a compensatory upregulation of CTBS as the cell attempts to maintain lysosomal function. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
A lectin that can increase the trafficking of glycoproteins to lysosomes, potentially increasing the substrate availability for CTBS and indirectly upregulating its activity to process the accumulated glycoproteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that may lead to an increased load of glycoproteins in lysosomes, indirectly promoting the upregulation of CTBS to enhance degradation capacity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
A thiol protease inhibitor which can lead to enhanced lysosomal stress and potentially induce the expression and activity of other lysosomal enzymes including CTBS to compensate for the inhibited proteolytic activity. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
A pan-caspase inhibitor that can affect apoptotic pathways and lead to increased autophagy and lysosome function, possibly upregulating lysosomal enzymes such as CTBS in the process. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
An inhibitor of autophagy that may result in increased lysosomal biogenesis as a compensatory response, potentially upregulating enzymes like CTBS. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
An ionophore that alters lysosomal pH and can modulate lysosomal enzyme activities, which may include an upregulation of CTBS activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
A drug that can influence the autophagic pathway and potentially impact lysosomal function and enzyme activity, including CTBS. | ||||||