Autophagy Inhibitor, 3-MA CAS: 5142-23-4
MF: C6H7N5
MW: 149.15

Autophagy Inhibitor, 3-MA (CAS 5142-23-4)

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Nomi alternativi: Autophagy Inhibitor, 3-MA is also known as 3-methyladenine.
Applicazione: Autophagy Inhibitor, 3-MA is a multi-use inhibitor that inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidy
Numero CAS: 5142-23-4
Purezza: ≥95%
Peso molecolare: 149.15
Formula molecolare: C6H7N5
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 (sc-201426) and Wortmannin (sc-3505), in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 γ. Autophagy Inhibitor, 3-MA is also known as 3-methyladenine, 3-methyladenine inhibitor, 3-MA, and 6-Amino-3-methylpurine.


Referenze

1. Caro, L.H., et al. 1988. Eur. J. Biochem. 175: 325-329. PMID: 3402459

2. Eskelinen, E.L., et al. 2002. Traffic. 3: 878-893. PMID: 12453151

3. Beugnet, A., et al. 2003. Biochem. J. 372: 555-566. PMID: 12611592

4. Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316: 845-852. PMID: 15033478

5. Canu, N., et al. 2005. J. Neurochem. 92: 1228-1242. PMID: 15715672

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml), 95% ethanol, and 1N NaOH heating (30 mg/ml).
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
300° C (lit.)
Punto di ebollizione :
240° C
Densità :
1.6 g/cm3
Indice di rifrazione :
n20D 1.81 (Predicted)
IC50 :
class III PI3K: IC50 = 4.5 mM
Valori pK :
pKb: 6.77 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
AU6520000
PubChem CID :
1673
Numero MDL :
MFCD00010531
Numero EC :
225-908-6
Registro Beilstein :
146087
SMILES :
CN1C=NC(=C2C1=NC=N2)N

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Autophagy Inhibitor, 3-MA (CAS 5142-23-4)  Citazioni prodotti

Vedi quanti altri hanno usato Autophagy Inhibitor, 3-MA (CAS 5142-23-4). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 90 totali

PMID: # 31257986  Unno, R.|Kawabata, T.|Taguchi, K.|Sugino, T.|Hamamoto, S.|Ando, R.|Okada, A.|Kohri, K.|Yoshimori, T.|Yasui, T.| et al. 2019. Autophagy. 1-15.

PMID: # 30362509  Gao, N.|Yao, X.|Jiang, L.|Yang, L.|Qiu, T.|Wang, Z.|Pei, P.|Yang, G.|Liu, X.|Sun, X.| et al. 2019. J. Cell. Physiol. 234: 5143-5152.

PMID: # 30831261  Liu, A.|Zhang, W.|Chen, Y.|Zhou, D.|Wang, Z.|Kang, J.|Wei, L.| et al. 2019. Photodiagnosis Photodyn Ther.

PMID: # 30677399  Wang, Z.|Tao, Y.|Qiu, T.|Yao, X.|Jiang, L.|Wang, N.|Wei, S.|Jia, X.|Pei, P.|Yang, G.|Liu, X.|Liu, S.|Sun, X.| et al. 2019. Chem. Biol. Interact. 300: 123-130.

PMID: # 30626699  Chao, H.|Lin, C.|Zuo, Q.|Liu, Y.|Xiao, M.|Xu, X.|Li, Z.|Bao, Z.|Chen, H.|You, Y.|Kochanek, PM.|Yin, H.|Liu, N.|Kagan, VE.|Bayır, H.|Ji, J.| et al. 2019. J. Neurosci. 39: 1930-1943.

PMID: # 30599220  D'Eliseo, D.|Pannucci, E.|Bernini, R.|Campo, M.|Romani, A.|Santi, L.|Velotti, F.| et al. 2019. J Ethnopharmacol. 233: 41-46.

PMID: # 30259142  Suda, Y.|Murakami, S.|Horimoto, T.| et al. 2019. Arch. Virol. 164: 255-260.

PMID: # 31327962  2019. Front Cell Neurosci. 13: 154.

PMID: # 29499203  Xu, DQ.|Toyoda, H.|Yuan, XJ.|Qi, L.|Chelakkot, VS.|Morimoto, M.|Hanaki, R.|Kihira, K.|Hori, H.|Komada, Y.|Hirayama, M.| et al. 2018. Exp. Cell Res. 365: 177-184.

PMID: # 29460131  Wang, Q.|He, WY.|Zeng, YZ.|Hossain, A.|Gou, X.| et al. 2018. Int Urol Nephrol. 50: 675-686.

Ciatazioni 1 a10 di 90 totali
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