CSDA Activators
Cold shock domain protein A (CSDA) activators represent a class of compounds that play a pivotal role in modulating the activity of CSDA, a protein characterized by its cold shock domain. The cold shock domain is a conserved nucleic acid-binding domain found in a variety of proteins across different organisms, ranging from bacteria to higher eukaryotes. CSDA itself is known to be involved in cellular responses to environmental stresses, including temperature fluctuations, and is implicated in the regulation of various cellular processes. The activators of CSDA are substances that enhance or modify the functional capabilities of this protein, potentially influencing its interactions with nucleic acids and participating in cellular adaptations to stress.
Chemically, CSDA activators may exhibit diverse structures and properties, as they need to interact specifically with the cold shock domain of the CSDA protein. The interaction between these activators and CSDA likely involves binding events that alter the conformation or dynamics of the protein, leading to downstream effects on its biological functions. Understanding the chemical nature of CSDA activators is crucial for unraveling the intricate mechanisms underlying the modulation of CSDA activity and its subsequent impact on cellular responses to environmental stressors. The exploration of CSDA activators provides valuable insights into the regulatory networks governing stress adaptation at the molecular level, offering a nuanced perspective on the dynamic interplay between cellular components and external stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, a direct activator of adenylate cyclase, enhances the production of cyclic AMP (cAMP) in cells. Elevated cAMP levels can lead to PKA activation, which in turn can phosphorylate and activate CSDA, enhancing its RNA-binding activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
This cell-permeable cAMP analogue directly activates PKA. As with Forskolin, this can lead to enhanced CSDA activity through phosphorylation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases (PDEs), enzymes that degrade cAMP. By inhibiting these enzymes, IBMX can indirectly increase cAMP levels and consequentially activate PKA, leading to enhanced CSDA function. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors, triggering a G-protein coupled cascade that activates adenylate cyclase, thereby increasing cAMP levels, activating PKA, and enhancing CSDA activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic compound similar to epinephrine. It, too, interacts with beta-adrenergic receptors, enhancing cAMP production and leading to CSDA activation via PKA. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of PDE4, a specific class of phosphodiesterases that degrade cAMP. By inhibiting PDE4, Rolipram indirectly increases cAMP levels, leading to PKA activation and enhanced CSDA function. | ||||||
Ro 20-1724 | 29925-17-5 | sc-200709 sc-200709A sc-200709B | 100 mg 1 g 5 g | $87.00 $426.00 $1574.00 | 17 | |
Like Rolipram, Ro 20-1724 is a PDE4 inhibitor. It increases cAMP levels, leading to PKA activation and enhanced CSDA function. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual inhibitor of PDE3 and PDE4, increasing cellular cAMP levels, which in turn activate PKA and enhance CSDA function. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a PDE3 inhibitor that elevates cAMP levels, leading to PKA activation and enhanced CSDA function. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a PDE1 inhibitor which can indirectly increase cAMP levels, thereby activating PKA and enhancing CSDA function. | ||||||