cryptdin 3 Activators
Defa3, a member of the defensin family, is predicted to enable protein homodimerization activity and plays a crucial role in responses to bacteria and xenobiotic stimuli. Located in the extracellular space, Defa3's function is intricately tied to its expression levels, which are influenced by various signaling pathways. Activation of Defa3 can occur through direct or indirect means. Direct activators include compounds like quercetin, resveratrol, and ursolic acid, which modulate specific pathways leading to enhanced Defa3 expression. Indirect activators, such as baicalein, curcumin, and genistein, impact signaling cascades like JAK-STAT and MAPK, indirectly promoting Defa3 transcription in response to stimuli.
Quercetin, for instance, acts as an indirect activator by inhibiting IKK and modulating NF-κB signaling, thereby influencing Defa3 expression in response to bacterial challenges. Similarly, resveratrol activates SIRT1, indirectly enhancing Defa3 transcription by deacetylating NF-κB p65. These intricate interactions highlight the complex regulatory network that governs Defa3 activation, providing potential avenues for further exploration in the context of host defense mechanisms.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid acting as a potential indirect activator of Defa3. Known to modulate NF-κB signaling by inhibiting IKK and preventing its phosphorylation, thereby influencing Defa3 expression in response to bacterial stimuli. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenol with implications in Defa3 activation. Activates SIRT1, leading to deacetylation of NF-κB p65, resulting in an enhanced transcriptional activity of Defa3 in response to xenobiotic stimuli. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Pentacyclic triterpene influencing Defa3 expression. Activates PPAR-γ, indirectly promoting Defa3 transcription in response to bacterial challenges through modulation of the PI3K/Akt pathway. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Flavone derivative with potential as an indirect Defa3 activator. Suppresses the JAK-STAT pathway, indirectly influencing Defa3 expression in response to bacterial and xenobiotic stimuli. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Polyphenol influencing Defa3 via multiple pathways. Modulates MAPK signaling by inhibiting p38 activation, indirectly promoting Defa3 expression in response to bacterial and xenobiotic stimuli. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Green tea polyphenol acting as an indirect activator of Defa3. Inhibits the PI3K/Akt pathway, influencing Defa3 expression in response to xenobiotic stimuli and bacterial challenges. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Isoflavone with potential Defa3 activating properties. Acts as a tyrosine kinase inhibitor, modulating JAK-STAT signaling and indirectly enhancing Defa3 expression in response to xenobiotic stimuli. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Flavanone influencing Defa3 expression. Modulates NF-κB signaling by inhibiting IκB degradation, indirectly promoting Defa3 transcription in response to bacterial stimuli. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Antioxidant with potential indirect Defa3 activating properties. Modulates Nrf2 signaling, influencing Defa3 expression in response to xenobiotic stimuli by enhancing antioxidant response elements. | ||||||
Baicalin | 21967-41-9 | sc-204638 sc-204638A sc-204638B sc-204638C | 1 mg 25 mg 1 g 5 g | $56.00 $112.00 $224.00 $265.00 | 4 | |
Flavonoid glycoside with potential Defa3 activation. Suppresses TLR4/NF-κB signaling, indirectly promoting Defa3 expression in response to bacterial stimuli. | ||||||