cryptdin 3 Inhibitors
Cryptdin 3 inhibitors are part of a class of antimicrobial peptides known as cryptdins, which are primarily produced by Paneth cells in the intestinal epithelium. Cryptdin 3, characterized by its cationic and amphipathic nature, plays a crucial role in the innate immune response by targeting a wide range of pathogens, including bacteria, fungi, and viruses. The peptide interacts with microbial membranes, typically through electrostatic attraction due to its positive charge, allowing it to insert itself into the lipid bilayer. This interaction can disrupt the integrity of the microbial cell membrane, leading to increased permeability and ultimately cell lysis. The unique structure of cryptdin 3, with its distinct α-helical region, facilitates this process, enabling the peptide to effectively neutralize various microbial threats.
Inhibitors of cryptdin 3 work by interfering with the peptide's ability to exert its antimicrobial effects. These inhibitors can disrupt the binding affinity of cryptdin 3 to microbial membranes, either by competing for the same binding sites or by altering the conformation of the peptide itself, thus diminishing its membrane-disrupting capabilities. The exploration of cryptdin 3 inhibitors provides valuable insights into the mechanisms underlying antimicrobial peptide function and resistance. Understanding how these inhibitors influence the activity of cryptdin 3 can enhance our knowledge of host-microbe interactions and the regulatory mechanisms that govern antimicrobial peptide activity. By studying these dynamics, researchers can uncover the complex relationships between antimicrobial peptides and microbial populations within the gut, furthering the understanding of intestinal homeostasis and immune regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gentamicin sulfate | 1405-41-0 | sc-203334 sc-203334A sc-203334F sc-203334B sc-203334C sc-203334D sc-203334E | 1 g 5 g 50 g 100 g 1 kg 2.5 kg 7.5 kg | $55.00 $175.00 $499.00 $720.00 $1800.00 $2600.00 $6125.00 | 3 | |
Gentamycin, an aminoglycoside antibiotic, directly inhibits Defa3 by binding to bacterial ribosomes, inhibiting protein synthesis. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $42.00 | 8 | |
Ciprofloxacin, a fluoroquinolone antibiotic, directly inhibits Defa3 by targeting bacterial DNA gyrase and topoisomerase IV, hindering DNA replication. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin, an ansamycin antibiotic, directly inhibits Defa3 by binding to bacterial RNA polymerase, blocking transcription. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol, a broad-spectrum antibiotic, directly inhibits Defa3 by inhibiting bacterial protein synthesis. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline, a broad-spectrum antibiotic, directly inhibits Defa3 by binding to bacterial ribosomes, inhibiting protein synthesis. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $66.00 $158.00 $204.00 $707.00 $3334.00 | 4 | |
Trimethoprim, a dihydrofolate reductase inhibitor, directly inhibits Defa3 by disrupting bacterial folate synthesis. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Clindamycin | 18323-44-9 | sc-337636A sc-337636B sc-337636C sc-337636 | 25 mg 50 mg 100 mg 1 g | $153.00 $367.00 $561.00 $809.00 | 2 | |
Clindamycin, a lincosamide antibiotic, directly inhibits Defa3 by binding to bacterial ribosomes, inhibiting protein synthesis. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $56.00 $240.00 $815.00 $1305.00 | 4 | |
Erythromycin, a macrolide antibiotic, directly inhibits Defa3 by binding to bacterial ribosomes, inhibiting protein synthesis. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Nitrofurantoin | 67-20-9 | sc-212399 | 10 g | $82.00 | ||
Nitrofurantoin, a nitrofuran antibiotic, directly inhibits Defa3 by damaging bacterial DNA and inhibiting bacterial enzymes. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||
Levofloxacin | 100986-85-4 | sc-252953 sc-252953B sc-252953A | 10 mg 250 mg 1 g | $39.00 $45.00 $53.00 | 3 | |
Levofloxacin, a fluoroquinolone antibiotic, directly inhibits Defa3 by targeting bacterial DNA gyrase and topoisomerase IV, hindering DNA replication. This inhibition influences the response to bacterium and xenobiotic stimuli, providing a targeted approach to modulating immune responses. | ||||||