cryptdin 22 Activators
Cryptdin 22, a protein predicted to enable protein homodimerization activity, plays a crucial role in various biological processes, particularly in the antimicrobial humoral immune response mediated by antimicrobial peptides. Its involvement in innate immune responses in mucosa, as well as defense responses to bacteria, highlights its significance in maintaining cellular defense mechanisms. The protein is located in the extracellular region, where it is predicted to be active in the extracellular space, emphasizing its role in extracellular defense against microbial threats. Orthologous to human genes like DEFA6 (defensin alpha 6), cryptdin 22 is a key component in the intricate network of genes orchestrating the body's defense against pathogens.
The activation of cryptdin 22 involves a complex interplay of signaling pathways and cellular processes. Various chemicals, such as resveratrol, butyrate, and curcumin, indirectly activate cryptdin 22 by modulating specific pathways. For example, resveratrol enhances antimicrobial humoral immune responses by influencing the NF-κB pathway, while butyrate, through histone acetylation, promotes chromatin structure changes leading to increased expression of antimicrobial peptides. These chemicals act as indirect activators, impacting pathways like MAPK, JAK/STAT, and PI3K/Akt, ultimately contributing to the upregulation of cryptdin 22. The intricacies of these interactions highlight the sophisticated regulatory mechanisms governing the activation of this vital protein in the context of innate immune responses.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenolic compound found in red grapes. Activates cryptdin 22 indirectly by modulating the NF-κB pathway. Enhances the expression of genes involved in antimicrobial humoral immune response, including cryptdin 22. Acts as a potent antioxidant and anti-inflammatory agent, influencing cellular responses. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Short-chain fatty acid involved in histone acetylation. Indirectly activates cryptdin 22 by influencing epigenetic regulation. Modifies chromatin structure, leading to increased expression of antimicrobial peptides. Acts as an HDAC inhibitor, impacting the acetylation status of histones and gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural polyphenol from turmeric. Acts as an indirect activator by targeting the MAPK signaling pathway. Modulates intracellular pathways, ultimately upregulating cryptdin 22 expression. Exhibits anti-inflammatory properties, influencing the cellular environment and promoting the antimicrobial immune response. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Phytochemical found in cruciferous vegetables. Indirectly activates cryptdin 22 by enhancing Nrf2-mediated signaling. Modulates antioxidant response elements, leading to increased expression of antimicrobial peptides. Acts as an inducer of phase II detoxification enzymes, influencing cellular defense mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid with antioxidant properties. Acts as an indirect activator by modulating the JAK/STAT pathway. Influences signaling cascades, leading to upregulation of cryptdin 22. Exhibits anti-inflammatory effects, impacting cellular processes involved in the innate immune response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate from green tea. Indirectly activates cryptdin 22 via AMPK activation. Modulates cellular energy sensing pathways, leading to increased expression of antimicrobial peptides. Exhibits antioxidant properties and influences signaling cascades related to the innate immune response. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Alkaloid with diverse pharmacological effects. Acts as an indirect activator by modulating the PI3K/Akt pathway. Influences cellular signaling, leading to upregulation of cryptdin 22. Exhibits anti-inflammatory properties, impacting pathways associated with the innate immune response. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Naturally occurring compound in cruciferous vegetables. Indirectly activates cryptdin 22 by influencing the AhR signaling pathway. Modulates gene expression related to antimicrobial humoral immune response, including cryptdin 22. Exhibits anti-inflammatory effects and impacts cellular processes involved in immune defense. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Flavonoid from Scutellaria baicalensis. Acts as an indirect activator by targeting the Wnt/β-catenin pathway. Modulates intracellular signaling, leading to upregulation of cryptdin 22. Exhibits anti-inflammatory properties and influences cellular processes associated with the innate immune response. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Carotenoid pigment found in tomatoes. Indirectly activates cryptdin 22 through modulation of the PI3K/Akt pathway. Influences cellular signaling, leading to increased expression of antimicrobial peptides. Exhibits antioxidant properties and impacts pathways associated with the innate immune response. | ||||||