cryptdin 22 Inhibitors
Cryptdin 22 inhibitors belong to a class of antimicrobial peptides known as cryptdins, which are produced predominantly by Paneth cells in the intestines. These peptides, including cryptdin 22, play a significant role in the innate immune system, contributing to the defense against a variety of pathogens such as bacteria, fungi, and viruses. Cryptdin 22 is characterized by its cationic nature and amphipathic structure, which facilitate its interaction with negatively charged microbial membranes. The unique amino acid composition and sequence of cryptdin 22 enhance its ability to disrupt microbial cell membranes, leading to membrane permeabilization and subsequent cell lysis. This mechanism is central to its function as a component of the host's first line of defense, helping to maintain the balance of the gut microbiome.
Inhibitors of cryptdin 22 can alter its antimicrobial activity by various means. These inhibitors may bind directly to the peptide, preventing it from adopting a conformation suitable for membrane insertion or disrupting its capacity to form pores within microbial membranes. Additionally, some inhibitors might interfere with the peptide's interaction with microbial targets by competing for binding sites or altering the structural integrity of microbial membranes. The study of cryptdin 22 inhibitors provides insights into the complex interactions between host defense mechanisms and microbial populations in the gut. Understanding how these inhibitors modulate the activity of cryptdin 22 can shed light on the regulatory processes that govern immune responses and microbial ecology, highlighting the intricate relationship between host organisms and their resident microorganisms in maintaining homeostasis within the gastrointestinal environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
Ciprofloxacin, a fluoroquinolone antibiotic, directly inhibits cryptdin 22 by interfering with bacterial DNA gyrase. This inhibition influences the antimicrobial humoral immune response and the innate immune response in mucosa. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $52.00 $103.00 $260.00 $364.00 $728.00 | 17 | |
Azithromycin, a macrolide antibiotic, directly inhibits cryptdin 22 by interfering with bacterial protein synthesis. This inhibition contributes to modulation of the antimicrobial humoral immune response mediated by antimicrobial peptides and the innate immune response in mucosa. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Tetracycline, a broad-spectrum antibiotic, directly inhibits cryptdin 22 by interfering with bacterial protein synthesis. This inhibition influences the antimicrobial humoral immune response and the innate immune response in mucosa. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, a rifamycin antibiotic, directly inhibits cryptdin 22 by interfering with bacterial RNA synthesis. This inhibition contributes to modulation of the antimicrobial humoral immune response mediated by antimicrobial peptides and the innate immune response in mucosa. | ||||||
Levofloxacin | 100986-85-4 | sc-252953 sc-252953B sc-252953A | 10 mg 250 mg 1 g | $40.00 $46.00 $54.00 | 3 | |
Levofloxacin, a fluoroquinolone antibiotic, directly inhibits cryptdin 22 by interfering with bacterial DNA gyrase. This inhibition influences the antimicrobial humoral immune response and the innate immune response in mucosa. | ||||||
Clarithromycin | 81103-11-9 | sc-205634 sc-205634A | 100 mg 250 mg | $77.00 $122.00 | 1 | |
Clarithromycin, a macrolide antibiotic, directly inhibits cryptdin 22 by interfering with bacterial protein synthesis. This inhibition influences the antimicrobial humoral immune response and the innate immune response in mucosa. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin, a macrolide antibiotic, directly inhibits cryptdin 22 by interfering with bacterial protein synthesis. This inhibition contributes to modulation of the antimicrobial humoral immune response mediated by antimicrobial peptides and the innate immune response in mucosa. | ||||||
Clindamycin | 18323-44-9 | sc-337636A sc-337636B sc-337636C sc-337636 | 25 mg 50 mg 100 mg 1 g | $156.00 $374.00 $572.00 $825.00 | 2 | |
Clindamycin, a lincosamide antibiotic, directly inhibits cryptdin 22 by interfering with bacterial protein synthesis. This inhibition influences the antimicrobial humoral immune response and the innate immune response in mucosa. | ||||||