CRP3 Activators
CRP3 activators consist of a variety of chemical compounds that indirectly influence the activity of CCAAT/enhancer-binding protein delta. These activators work through several cellular mechanisms and pathways. For instance, Dexamethasone, a glucocorticoid receptor agonist, can enhance glucocorticoid receptor-mediated signaling, leading to the upregulation of CRP3 expression. Similarly, compounds like Cyclic AMP and Forskolin elevate cAMP levels, which activate protein kinase A (PKA). PKA activation can lead to enhanced CREB activity, a transcription factor that can upregulate CRP3.
Other chemicals in this class include IBMX, a non-selective phosphodiesterase inhibitor that raises cAMP and cGMP levels, potentially enhancing CRP3 activation through PKA pathways. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can modulate transcription factors influencing CRP3 expression. Additionally, Retinoic acid and β-estradiol work through receptor-mediated mechanisms, modulating gene expression patterns that can include CRP3 upregulation. Epidermal Growth Factor (EGF) and Insulin are examples of compounds that activate specific receptor signaling pathways, leading to downstream signaling that affects CRP3 expression. Lastly, Sodium Butyrate and 5-Azacytidine, a histone deacetylase inhibitor and a DNA methyltransferase inhibitor, respectively, can alter chromatin structure and DNA methylation, potentially enhancing CRP3 expression.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid receptor agonist; enhances glucocorticoid receptor-mediated signaling, which can upregulate CRP3 expression. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Second messenger; increases in cAMP can activate PKA, leading to enhanced CREB activity, which can upregulate CRP3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective phosphodiesterase inhibitor; elevates cAMP and cGMP levels, potentially enhancing CRP3 activation via PKA. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Adenylyl cyclase activator; increases cAMP, which can activate PKA and subsequently influence CRP3 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC); PKC can modulate transcription factors influencing CRP3 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Modulates retinoic acid receptors, influencing gene expression patterns that can include CRP3 upregulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Glycogen synthase kinase-3 (GSK-3) inhibitor; modulates Wnt signaling, potentially affecting CRP3 expression. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Activates insulin receptor signaling, influencing transcription factors and pathways that may include CRP3 upregulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor; alters chromatin structure, potentially enhancing CRP3 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor; can lead to demethylation and activation of genes including possibly CRP3. | ||||||