CrkRS Activators
CrkRS, also known as cytokine receptor-like factor 2 (CRLF2), is a protein primarily implicated in hematopoietic cell development and function. It is a type I cytokine receptor that forms a homodimer, playing a pivotal role in the regulation of cell proliferation, survival, and differentiation, particularly within the hematopoietic system. CrkRS is prominently expressed in various hematopoietic cell types, including lymphoid and myeloid lineages, where it exerts its influence on key cellular processes crucial for immune response and hematopoiesis. Functionally, CrkRS acts as a crucial mediator of intracellular signaling cascades initiated upon ligand binding, orchestrating downstream events pivotal for cellular fate determination and immune homeostasis. Its involvement in critical cellular pathways underscores its significance in hematopoietic regulation and immune modulation.
The activation of CrkRS predominantly occurs through ligand-induced dimerization and subsequent activation of associated Janus kinases (JAKs), leading to the phosphorylation of specific tyrosine residues within the cytoplasmic domain of CrkRS. Phosphorylation of these tyrosine residues serves as docking sites for downstream signaling molecules, including signal transducers and activators of transcription (STATs), which upon recruitment, undergo phosphorylation and subsequent nuclear translocation, culminating in the transcriptional regulation of target genes involved in cell growth, survival, and differentiation. Additionally, CrkRS activation is intricately linked to the activation of various mitogen-activated protein kinase (MAPK) cascades, including the extracellular signal-regulated kinase (ERK) pathway, further amplifying the signaling output and modulating cellular responses. Collectively, the activation of CrkRS represents a crucial checkpoint in hematopoietic regulation, orchestrating intricate signaling networks pivotal for immune cell development and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that causes DNA strand breaks. These breaks can stimulate the DNA damage response pathway, in which CDK12 is a key player, catalyzing the phosphorylation of the C-terminal domain (CTD) of RNA polymerase II, facilitating transcription of DNA damage response genes. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin hydrochloride is an anthracycline antibiotic that intercalates into DNA and inhibits topoisomerase II, leading to DNA damage. This damage activates the DNA damage response pathway, where CDK12 aids in the transcription of DNA repair genes. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms platinum-DNA adducts, leading to DNA damage. This triggers the DNA damage response pathway, in which CDK12 is involved by phosphorylating the CTD of RNA polymerase II, promoting transcription of DNA repair genes. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor that increases DNA breaks by inhibiting the repair of single-strand DNA breaks. The increased DNA damage can stimulate the DNA damage response pathway, where CDK12 can promote transcription of DNA repair genes. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is a selective ATR inhibitor that increases DNA damage by preventing the repair of DNA double-strand breaks. This can stimulate CDK12's role in the DNA damage response pathway, where it promotes transcription of DNA repair genes. | ||||||
AZ20 | 1233339-22-4 | sc-503186 | 5 mg | $255.00 | 1 | |
AZ20 is another selective ATR inhibitor that increases DNA damage by preventing the repair of DNA double-strand breaks. This can stimulate the DNA damage response pathway, where CDK12 plays a role in promoting transcription of DNA repair genes. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
ATM Kinase Inhibitor increases DNA damage by preventing the repair of DNA double-strand breaks. This can stimulate the DNA damage response pathway, where CDK12 plays a role in promoting transcription of DNA repair genes. | ||||||
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
KU-60019 is another ATM inhibitor that increases DNA damage by preventing the repair of DNA double-strand breaks. This can stimulate the DNA damage response pathway, where CDK12 plays a role in promoting transcription of DNA repair genes. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
NU7441 is a DNA-PK inhibitor that increases DNA damage by preventing the repair of DNA double-strand breaks. This can stimulate the DNA damage response pathway, where CDK12 plays a role in promoting transcription of DNA repair genes. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinating enzyme (DUB) inhibitor that can disrupt overall protein homeostasis. This disruption may lead to cellular stress responses, including the DNA damage response pathway, where CDK12 plays a role in promoting transcription of DNA repair genes. | ||||||