CRISP-4 Activators
CRISP-4 (Cysteine-Rich Secretory Protein 4) plays a vital role in fertilization, enabling calcium channel regulator activity and influencing processes such as sperm binding to the zona pellucida and the regulation of the acrosome reaction. The intricate orchestration of these events is essential for successful fertilization. Activation of CRISP-4 involves a range of chemicals that modulate calcium homeostasis and channel regulation. Compounds like Dantrolene, Ionomycin, and Thapsigargin directly impact calcium levels, positively influencing CRISP-4 activity and enhancing its role in regulating sperm interactions with the zona pellucida. Ginsenoside Rg1 and Nifedipine modulate calcium channels, while Epigallocatechin Gallate (EGCG) and Verapamil influence intracellular calcium, all contributing to the activation of CRISP-4.
Trehalose, A23187, Forskolin, Xestospongin C, and Raloxifene also participate in the activation of CRISP-4 by influencing calcium channel regulation and contributing to the delicate balance required for successful fertilization. Each compound plays a distinct role in modulating the cellular and biochemical pathways associated with CRISP-4 activation. In summary, the comprehensive understanding of CRISP-4 and its activation mechanisms sheds light on the intricate processes involved in fertilization. The modulation of calcium homeostasis and channel regulation by various chemicals highlights the complex network of events that CRISP-4 governs, underscoring its significance in reproductive biology.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene stimulates CRISP-4 by inhibiting calcium release from the sarcoplasmic reticulum, enhancing calcium channel regulator activity. This leads to increased binding activity of sperm to the zona pellucida and regulation of the acrosome reaction, crucial processes in fertilization. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin activates CRISP-4 by inducing calcium influx, promoting calcium channel regulator activity. This positively influences the regulation of acrosome reaction and enhances the binding of sperm to the zona pellucida, crucial events in the fertilization process. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin stimulates CRISP-4 by inhibiting endoplasmic reticulum calcium ATPase, leading to increased calcium levels. This enhances calcium channel regulator activity, positively impacting sperm binding to the zona pellucida and regulation of the acrosome reaction during fertilization. | ||||||
Ginsenoside Rg1 | 22427-39-0 | sc-205708 sc-205708A | 5 mg 10 mg | $265.00 $486.00 | ||
Ginsenoside Rg1 activates CRISP-4 by modulating calcium homeostasis, promoting calcium channel regulator activity. This influences the regulation of acrosome reaction and enhances sperm binding to the zona pellucida, critical events in the process of fertilization. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine stimulates CRISP-4 by blocking L-type calcium channels, enhancing calcium channel regulator activity. This positively influences acrosome reaction regulation and sperm binding to the zona pellucida, crucial processes in fertilization. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates CRISP-4 by modulating intracellular calcium levels, promoting calcium channel regulator activity. This positively impacts acrosome reaction regulation and enhances sperm binding to the zona pellucida, pivotal events in the process of fertilization. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil stimulates CRISP-4 by blocking calcium channels, enhancing calcium channel regulator activity. This positively influences the regulation of acrosome reaction and enhances sperm binding to the zona pellucida, crucial events in the process of fertilization. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose activates CRISP-4 by modulating intracellular calcium levels, promoting calcium channel regulator activity. This positively influences the regulation of acrosome reaction and enhances sperm binding to the zona pellucida, crucial processes in fertilization. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 activates CRISP-4 by facilitating calcium ionophore-induced calcium influx, promoting calcium channel regulator activity. This positively influences the regulation of acrosome reaction and enhances sperm binding to the zona pellucida, crucial events in fertilization. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $510.00 | 14 | |
Xestospongin C activates CRISP-4 by inhibiting inositol trisphosphate receptors, enhancing calcium channel regulator activity. This positively influences the regulation of acrosome reaction and enhances sperm binding to the zona pellucida, critical events in fertilization. | ||||||