CRISP-4 Inhibitors
CRISP-4 inhibitors constitute a distinctive class of compounds targeting the cysteine-rich secretory protein (CRISP) family, specifically the CRISP-4 variant. These proteins are characterized by their ability to bind to and modulate the activity of various ion channels and receptors, playing significant roles in cellular signaling and communication. CRISP-4, in particular, is known for its involvement in processes such as cell adhesion, immune response modulation, and the regulation of ion flow across cellular membranes. By inhibiting CRISP-4, these compounds aim to disrupt the interactions and signaling pathways associated with this protein, leading to altered cellular behavior and responses.
The design and development of CRISP-4 inhibitors typically involve high-throughput screening methods and structure-activity relationship (SAR) studies to identify small molecules or peptides that effectively bind to the CRISP-4 protein. These inhibitors are evaluated for their potency and selectivity, often employing biochemical assays to assess their impact on CRISP-4 function and downstream signaling events. Research into CRISP-4 inhibitors is focused on elucidating the mechanisms through which CRISP proteins influence cellular processes, as well as understanding their role in various biological systems. As such, CRISP-4 inhibitors serve as essential tools for dissecting the complex interactions of CRISP proteins and their contributions to cellular signaling pathways, providing valuable insights into the functional significance of this protein family in various contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine, a dihydropyridine calcium channel blocker, inhibits CRISP-4 indirectly by preventing the influx of calcium ions through L-type calcium channels, disrupting the signaling cascade involved in calcium channel regulator activity. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red acts as a non-specific inhibitor by blocking multiple types of calcium channels, including those involved in CRISP-4 regulation. It disrupts the calcium-dependent processes associated with sperm binding to zona pellucida and the regulation of the acrosome reaction. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits CRISP-4 indirectly by blocking receptor-operated calcium channels (ROCs), essential for calcium channel regulator activity. By interfering with the influx of calcium ions, SKF-96365 disrupts the processes upstream of sperm binding to zona pellucida and the regulation of acrosome reaction. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a calcium channel blocker, inhibits CRISP-4 indirectly by targeting L-type calcium channels, disrupting the calcium-dependent processes associated with calcium channel regulator activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits CRISP-4 indirectly by modulating ryanodine receptors, impacting calcium release from the endoplasmic reticulum and influencing calcium channel regulator activity. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB inhibits CRISP-4 indirectly by blocking IP3 receptors and transient receptor potential (TRP) channels, disrupting intracellular calcium signaling pathways essential for calcium channel regulator activity. | ||||||
NNC 55-0396 | 357400-13-6 | sc-203647A sc-203647 | 5 mg 10 mg | $250.00 $421.00 | 2 | |
NNC 55-0396 inhibits CRISP-4 indirectly by blocking store-operated calcium entry (SOCE), disrupting the replenishment of intracellular calcium stores and influencing calcium channel regulator activity. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a calcium channel blocker, inhibits CRISP-4 indirectly by targeting L-type calcium channels, disrupting the calcium-dependent processes associated with calcium channel regulator activity. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $153.00 $357.00 | 4 | |
Gadolinium(III) chloride inhibits CRISP-4 indirectly by blocking stretch-activated channels, disrupting calcium influx and influencing calcium channel regulator activity. | ||||||