Date published: 2026-5-30

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CRHSP-24 Inhibitors

CRHSP-24 inhibitors represent a novel and distinctive class of chemical compounds designed to modulate the activity of the Corticotropin-Releasing Hormone (CRH) Signaling Pathway-24 (CRHSP-24). The CRHSP-24 pathway plays a pivotal role in the regulation of stress response and homeostasis within the central nervous system. At the molecular level, CRHSP-24 is intricately involved in the intricate signaling cascades triggered by the release of corticotropin-releasing hormone (CRH), a neuropeptide that orchestrates the body's stress response. The inhibitors belonging to the CRHSP-24 class function by selectively binding to key components of this pathway, thereby modulating its downstream effects.

CRHSP-24 inhibitors are characterized by their specific chemical arrangements, which enable them to interact with crucial proteins and receptors involved in the CRHSP-24 signaling cascade. Through this targeted interaction, these inhibitors exert a regulatory influence on the intricate molecular machinery responsible for stress response modulation. The pharmacological activity of CRHSP-24 inhibitors involves a nuanced interplay with components such as CRH receptors and associated proteins, ultimately influencing the signaling dynamics within neural circuits. As a result, these inhibitors have the potential to provide valuable insights into the physiological and molecular mechanisms underlying stress response regulation.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

Verapamil can affect calcium signaling pathways, which could influence the activity of CARHSP1 given its calcium-binding nature.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

PD98059 inhibits the MAPK/ERK pathway, which can have downstream effects on stress response elements potentially regulated by CARHSP1.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 targets the JNK signaling pathway, which can alter stress responses and mRNA stability mechanisms involving CARHSP1.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 modulates the p38 MAPK pathway, which is implicated in stress response and could interact with the function of CARHSP1.

BAPTA/AM

126150-97-8sc-202488
sc-202488A
25 mg
100 mg
$138.00
$458.00
61
(2)

BAPTA sequesters calcium ions, potentially affecting CARHSP1's activity by altering calcium homeostasis.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$62.00
$85.00
$356.00
155
(1)

BAY 11-7082 inhibits NF-kB, a transcription factor involved in inflammatory responses, which could intersect with CARHSP1's role in stress responses.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 inhibits PI3K, affecting the AKT signaling pathway which might have implications for CARHSP1's regulation of mRNA stability in stress conditions.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG132 inhibits proteasome activity, potentially affecting protein turnover and stress response pathways relevant to CARHSP1's function.

Geldanamycin

30562-34-6sc-200617B
sc-200617C
sc-200617
sc-200617A
100 µg
500 µg
1 mg
5 mg
$39.00
$59.00
$104.00
$206.00
8
(1)

Geldanamycin binds to HSP90, affecting its chaperone function which could have downstream effects on proteins regulated by CARHSP1.

Mifepristone

84371-65-3sc-203134
100 mg
$61.00
17
(1)

Mifepristone antagonizes glucocorticoid receptors, potentially influencing stress response pathways and mRNA stability processes involving CARHSP1.