CREBRF Activators
CREBRF activators comprise a spectrum of chemical compounds that directly or indirectly enhance the functional activity of the CREBRF protein by modulating various biochemical pathways. Forskolin, IBMX, and Isoproterenol elevate intracellular cAMP concentrations, which leads to the activation of Protein Kinase A (PKA). PKA can phosphorylate CREBRF, thereby enhancing its role in metabolic regulation, including its influence on energy balance and adipocyte function. In parallel, adenosine and glucagon also raise cAMP levels and PKA activity, further potentiating the phosphorylation and activity of CREBRF in energy homeostasis. Lithium Chloride, while not directly linked to CREBRF, inhibits GSK-3β, potentially impacting metabolic pathways that indirectly affect CREBRF's function. Similarly, Nicotinamide riboside, through its NAD+ enhancing properties, can activate sirtuins, which may influence CREBRF activity by deacetylation.
The fatty acids Oleic Acid and Palmitic Acid, as well as the thiazolidinediones Rosiglitazone,Pioglitazone, and Ciglitazone, act as activators of PPARs, with a pronounced effect from PPARγ agonists, orchestrating a regulatory cascade that culminates in the enhanced activity of CREBRF. These compounds effectively amplify CREBRF's functions in lipid metabolism and adipogenesis, pivotal processes for maintaining energy equilibrium within the cell. The activation of PPARs by these fatty acids and PPARγ agonists establishes a conducive environment for CREBRF to exert its regulatory effects on lipid handling and adipocyte differentiation. The concerted actions of these diverse chemical activators ensure that CREBRF's activity is upregulated, facilitating its regulatory capacity in the complex network of metabolic control, without necessitating an increase in its expression levels or relying on direct activation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA (Protein Kinase A). PKA can phosphorylate CREBRF, leading to its enhanced functional activity in processes such as the regulation of metabolic functions and energy homeostasis. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which increases intracellular levels of cAMP and activates PKA. This activation can enhance the phosphorylation and activity of CREBRF, influencing its role in metabolic regulation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β (Glycogen synthase kinase 3 beta), which can lead to the activation of Wnt signaling pathway. Although CREBRF is not directly involved in Wnt signaling, the pathway influences metabolic processes that can affect CREBRF's function related to glucose and lipid metabolism. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid is a monounsaturated fatty acid that can activate peroxisome proliferator-activated receptors (PPARs). Activation of PPARs can lead to the regulation of CREBRF, which is involved in lipid metabolism and adipogenesis. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic Acid is a saturated fatty acid that can also activate PPARs, potentially enhancing the activity of CREBRF in lipid metabolism and adipocyte differentiation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a PPARγ agonist that can enhance the activity of CREBRF by influencing adipocyte differentiation and lipid metabolism, which are processes regulated by CREBRF. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases intracellular cAMP levels, thereby activating PKA, which can then phosphorylate and enhance the activity of CREBRF. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine activates adenosine receptors, which can influence cAMP production and PKA activity, potentially enhancing the phosphorylation and functional activity of CREBRF. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside is a precursor of NAD+, which can activate sirtuins. Sirtuins could potentially deacetylate CREBRF, thereby enhancing its activity related to energy metabolism. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, another PPARγ agonist, can enhance CREBRF activity by modulating adipogenesis and lipid metabolism, processes that CREBRF is known to influence. | ||||||