Date published: 2026-4-1

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CREBRF Inhibitors

CREBRF inhibitors are a class of chemical compounds that primarily target and modulate the activity of the CREBRF protein within the human body. CREBRF, short for cAMP-Responsive Element-Binding Protein, Regulator Factor, is a relatively newly discovered protein that plays a crucial role in regulating energy homeostasis and metabolic processes. This protein is primarily expressed in adipose tissue, liver, and skeletal muscle, where it exerts control over glucose and lipid metabolism. CREBRF inhibitors, as the name suggests, are substances designed to interfere with the function of CREBRF, either by blocking its activity or modulating it to achieve a specific biological effect.

CREBRF can lead to alterations in metabolic processes, such as glucose uptake, insulin sensitivity, and lipid storage. Researchers have been exploring CREBRF inhibitors as potential tools to gain a deeper understanding of these metabolic pathways and their involvement in conditions like obesity, diabetes, and related metabolic disorders. The development and study of CREBRF inhibitors have provided valuable insights into the intricate network of molecular regulators that govern energy balance within the human body. By targeting CREBRF, researchers aim to unravel the complexities of metabolic regulation, paving the way for potential advancements in our understanding of these fundamental processes and, potentially, the development of novel interventions in the future.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

This compound inhibits the c-Jun N-terminal kinase (JNK) signaling pathway, which could modulate the transcriptional activity of downstream targets, potentially affecting CREBRF's regulatory roles.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

A p38 MAP kinase inhibitor, this chemical might influence cellular stress responses that could intersect with CREBRF's function in the endoplasmic reticulum.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

As a PI3K inhibitor, LY294002 can interfere with the PI3K/Akt signaling pathway, which might impact CREBRF's role in cellular growth and metabolism.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

This mTOR inhibitor is known to play a role in cell growth and proliferation, potentially influencing CREBRF's regulatory functions indirectly.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

An MEK inhibitor that could alter the MAPK/ERK pathway, potentially affecting pathways that CREBRF could regulate.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

A ROCK inhibitor that might affect cellular cytoskeleton dynamics, which could possibly be related to CREBRF's regulatory scope.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

As an inhibitor of PI3K, wortmannin might have an impact on cellular processes that CREBRF is involved in.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$94.00
$227.00
30
(1)

An Src family kinase inhibitor, potentially influencing signaling pathways that could intersect with CREBRF's function.

Gefitinib

184475-35-2sc-202166
sc-202166A
sc-202166B
sc-202166C
100 mg
250 mg
1 g
5 g
$63.00
$114.00
$218.00
$349.00
74
(2)

This EGFR inhibitor may have downstream effects on signaling pathways that indirectly affect CREBRF's activity.

Gö 6983

133053-19-7sc-203432
sc-203432A
sc-203432B
1 mg
5 mg
10 mg
$105.00
$299.00
$474.00
15
(1)

A PKC inhibitor that can modulate various signaling pathways, possibly affecting CREBRF's role in the cell.