CRB1 Activators
CRB1 activators constitute a category of chemical compounds that are specifically designed to modulate the activity of the protein CRB1 (Crumbs homolog 1), which is a critical component of the Crumbs protein complex. CRB1 is integral to the establishment and maintenance of epithelial cell polarity, and it contributes significantly to the proper formation and function of the adherens junctions in retinal cells. The protein is known to interact with other proteins such as PALS1 and PATJ to form the Crumbs complex, which is essential for the correct localization and functioning of the complex in cellular polarity and tight junction formation.
The activation of CRB1 by these compounds can occur through direct or indirect mechanisms. Direct CRB1 activators bind to CRB1 and induce a conformational change that promotes its interaction with its partner proteins within the Crumbs complex, enhancing their stabilization at the cell membrane and influencing the complex's role in maintaining cellular architecture. By augmenting the proper localization and function of CRB1, direct activators could thereby support the integrity of epithelial layers, such as the retina, and the organization of cellular structures. Indirect CRB1 activators could influence the activity of CRB1 through the regulation of signaling pathways that affect the expression levels of CRB1 or its post-translational modifications. Such modifications could include phosphorylation, ubiquitination, or other molecular alterations that can impact the stability, localization, or protein-protein interactions of CRB1. Additionally, indirect activators might modulate the cellular environment or the activity of other proteins that interact with the Crumbs complex, thereby influencing the function of CRB1 within this complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
All-trans-retinoic acid is a metabolite of Vitamin A which is known to activate the retinoic acid receptor (RAR). RAR activation can lead to the upregulation of CRB1 through the regulation of gene expression. | ||||||
25-Hydroxyvitamin D3 monohydrate | 63283-36-3 | sc-238445 sc-238445A | 1 mg 2.5 g | $110.00 $4089.00 | ||
25-Hydroxyvitamin D3 is a precursor of the active form of Vitamin D3. Vitamin D3 can regulate gene expression through the vitamin D receptor (VDR). This regulatory action can lead to the upregulation of CRB1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates protein kinase A (PKA). PKA can then phosphorylate certain proteins that can interact with CRB1, enhancing its functional activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases intracellular cAMP levels. Elevated cAMP levels can activate PKA, which can phosphorylate proteins that interact with CRB1, enhancing its functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate proteins that interact with CRB1, enhancing its functional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor. By inhibiting histone deacetylase, sodium butyrate promotes a more relaxed chromatin state, which can lead to the upregulation of CRB1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC). PKC can phosphorylate proteins that interact with CRB1, enhancing its functional activity. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA is an omega-3 fatty acid that can modulate the fluidity of cell membranes, possibly influencing the function of membrane proteins like CRB1. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is an activator of the NRF2 pathway, which can protect cells from oxidative stress. By reducing oxidative stress, curcumin can indirectly enhance the functional activity of CRB1. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
EPA is an omega-3 fatty acid that can modulate the fluidity of cell membranes, possibly influencing the function of membrane proteins like CRB1. | ||||||