CR16 Activators
Diving into the complex cellular interactions of CR16 reveals a nuanced understanding of how various chemical agents can modulate its activity. CR16's association with actin-related proteins underscores its involvement in actin dynamics. Therefore, any agent that influences actin's polymeric state can indirectly affect CR16. Okadaic Acid and Calyculin A, both serine/threonine phosphatase, can enhance actin polymerization processes. The effects of these chemicals reverberate through the cellular landscape, and given CR16's association with actin-regulating proteins, its activity is likely influenced.
Actin-binding agents such as Cytochalasin D, Phalloidin, Latrunculin A, and Jasplakinolide directly modulate actin dynamics. Their distinct mechanisms, either stabilizing or destabilizing actin filaments, can create an environment where CR16's interactions with other proteins are either favored or disrupted. Similarly, the ROCK, Y-27632, and the PKC activator, PDBu, alter actin filament organization or activate pathways, respectively, that govern actin dynamics. This further reaffirms that actin's polymeric state and its associated pathways are crucial for CR16's activity. Lastly, the interplay between actin and microtubules in cells cannot be ignored. Agents like Nocodazole and Paclitaxel, which modulate microtubule dynamics, can indirectly cast effects on the actin cytoskeleton. This cascade of cellular effects touches CR16 and its associated pathways. By dissecting the chemical agents that can influence actin and its interplay with other cellular structures, we obtain a clearer view of how CR16 can be modulated, offering avenues to further study its cellular roles and interactions.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Serine/threonine phosphatase inhibitor. By inhibiting these phosphatases, Okadaic Acid can impact pathways that regulate actin dynamics, potentially influencing the activity of CR16 which is known to associate with actin modulating proteins like WAS/WASL. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits serine/threonine phosphatases. This can enhance actin polymerization processes, indirectly influencing CR16 due to its known interactions with actin-related proteins. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
A polycationic antibiotic that can interfere with phospholipid binding, potentially affecting actin cytoskeleton dynamics. Given CR16's role in actin modulation, changes in actin dynamics can indirectly modulate its activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An actin polymerization inhibitor. While it primarily prevents actin filament elongation, its effects can propagate through the actin regulation machinery, potentially influencing proteins like CR16. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments and prevents their disassembly. This alteration in actin dynamics can propagate effects to proteins interacting with the actin cytoskeleton, like CR16. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin monomers and prevents their polymerization. Altering the equilibrium between monomeric and filamentous actin can indirectly affect CR16, which associates with actin-regulatory proteins. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor that can modulate actin filament organization and cell contractility. Given that CR16 interacts with proteins that modulate actin dynamics, Y-27632 can indirectly influence CR16 by altering actin-related processes. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
PKC activator. By modulating PKC activity, PDBu can influence pathways and proteins that regulate actin dynamics. This has the potential to indirectly modulate the activity of CR16 due to its association with the actin cytoskeleton. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Myosin II inhibitor, influencing actin-myosin interactions and thus potentially affecting actin dynamics and proteins like CR16 that are associated with actin regulation. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Actin filament stabilizer, affecting actin dynamics and potentially modulating the activity of actin-interacting proteins like CR16. | ||||||