CPSF2 Activators
CPSF2, or Cleavage and Polyadenylation Specificity Factor 2, plays a pivotal role in the post-transcriptional modification of pre-mRNA in eukaryotic cells. It is a key component of the cleavage and polyadenylation machinery that facilitates the maturation of messenger RNA, an essential step in the conversion of genetic information from DNA to functional proteins. CPSF2 is part of a larger complex that recognizes the polyadenylation signal in the nascent pre-mRNA and catalyzes the cleavage that is necessary for poly(A) tail addition. The regulation of CPSF2 expression is therefore intimately tied to the regulation of gene expression at large, affecting a broad array of cellular processes and functions. Given this regulatory role, CPSF2 expression is finely tuned within the cell, but certain chemical compounds have been identified that can potentially upregulate its expression, affecting the overall gene expression landscape.
Research into the modulation of CPSF2 expression has identified various non-peptidic chemical compounds that might serve as activators of its expression. For instance, forskolin is known to raise intracellular cAMP levels, which can lead to the activation of PKA and subsequent upregulation of transcription factors that may enhance CPSF2 transcription. Similarly, retinoic acid, by binding to its nuclear receptors, has been shown to stimulate transcription of genes through retinoic acid response elements. Other chemical activators such as dexamethasone and trichostatin A, a glucocorticoid and histone deacetylase inhibitor respectively, are known to upregulate gene expression by promoting transcription factor binding to glucocorticoid response elements and by altering chromatin structure to allow transcriptional machinery access to specific genes. Even small molecules like sodium butyrate and epigallocatechin gallate have been observed to influence the expression of a variety of genes, possibly including CPSF2, through mechanisms involving histone modification and the activation of cellular signaling pathways. These and other compounds are subjects of ongoing research to better understand the complex regulatory networks that control gene expression through proteins like CPSF2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin can elevate intracellular cAMP, which might activate protein kinase A (PKA) and subsequently upregulate transcription factors that increase CPSF2 gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid has the ability to bind to retinoid receptors, which can dimerize and bind to DNA response elements, potentially stimulating CPSF2 gene transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
As a glucocorticoid, Dexamethasone might bind to glucocorticoid receptors leading to the activation of glucocorticoid response elements and upregulation of the CPSF2 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound inhibits DNA methyltransferase, leading to DNA demethylation, which can remove transcriptional repression and stimulate CPSF2 gene transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol can bind estrogen receptors, leading to transcription factor recruitment at estrogen response elements, which may induce CPSF2 gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase 3 (GSK-3), leading to activation of Wnt signaling and possible upregulation of gene transcription including CPSF2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate’s inhibition of histone deacetylase can cause hyperacetylation of histones, enhancing transcriptional activation and potentially upregulating CPSF2 gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol may activate several signaling pathways, including those involving nuclear factor-kappaB (NF-κB), which might stimulate the transcription of the CPSF2 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to activate transcription factors like NF-κB and activate protein kinases, which could lead to the upregulation of the CPSF2 gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might activate the sirtuin pathway, leading to deacetylation of transcription factors or cofactors involved in the upregulation of CPSF2 gene expression. | ||||||