CPSF2 Inhibitors

CPSF2 inhibitors encompass compounds that have the ability to modulate the process of mRNA cleavage and polyadenylation indirectly by targeting upstream or associated cellular processes. The compounds listed are not direct inhibitors but affect various aspects of transcription, mRNA export, splicing, and other cellular processes that are prerequisite to or concurrent with the function of CPSF2. Inhibitors can lead to a reduction in RNA polymerase II activity, which is essential for the synthesis of pre-mRNA that CPSF2 processes. Similarly, inhibitors can disrupt the function of transcription elongation factors, leading to alterations in the mRNA synthesis that precedes cleavage and polyadenylation.

CPSF2 inhibitors target the DNA template itself, thereby potentially altering the availability or structure of pre-mRNA for processing by CPSF2. They also affect post-transcriptional processes like translation and splicing, which can lead to cellular stress responses that may secondarily influence CPSF2 function. Additionally, CPSF2 inhibitors affect chromatin structure and gene expression regulation, which can, in turn, impact the expression levels and activity of components of the mRNA processing machinery, including CPSF2. They also inhibit nuclear export proteins can also indirectly influence CPSF2 function by altering the balance of nuclear and cytoplasmic RNA, potentially affecting the feedback mechanisms that regulate mRNA processing. Overall, these compounds can affect CPSF2 activity by modulating the cellular environment, gene expression patterns, and the availability of pre-mRNA substrates required for efficient cleavage and polyadenylation.