cPKC βI Activators
cPKC βI Activators are a diverse array of chemical compounds that indirectly or directly enhance the functional activity of cPKC βI through a variety of mechanisms. Compounds like Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 bind to the C1 regulatory domain of cPKcPKC βI Activators, which include a range of chemical compounds, facilitate the activation and function of conventional Protein Kinase C beta I through diverse biochemical mechanisms. Direct activators such as Phorbol 12-myristate 13-acetate (PMA), Bryostatin 1, Ingenol Mebutate, Prostratin, 1,2-Dioctanoyl-sn-glycerol (DiC8), and Indolactam V function by mimicking the natural ligand diacylglycerol (DAG) or by binding to the C1 domain of cPKC βI, which leads to its membrane translocation and subsequent activation. This translocation is crucial for the phosphorylation of downstream targets that regulate cellular processes such as proliferation, differentiation, and inflammatory responses. Paradoxically, Bisindolylmaleimide I (BIM I) can also enhance cPKC βI activity at low concentrations by inducing a conformational change that increases its kinase activity, despite being a selective inhibitor at higher concentrations.
Moreover, indirect activators like Deoxycholic acid and Oleic acid influence cPKC βI activity by modulating the cellular membrane composition and fluidity, thereby facilitating the enzyme's access to its cofactors and target substrates within the membrane environment. Sphingosine and Ceramide, as lipid second messengers, play roles in sphingolipid signaling pathways that can lead to the activation of cPKC βI by affecting membrane dynamics. Similarly, Arachidonic acid, through its impact on membrane lipid composition, indirectly enhances the enzyme's interaction with its cofactors, promoting the functional activation of cPKC βI. These activators collectively operate to potentiate cPKC βI signaling pathways, essential for the regulation of various cellular responses without the need for upregulating the expression or direct activation of the enzyme.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of cPKC βI by mimicking diacylglycerol (DAG), a physiological activator of PKC. By binding to the DAG-sensitive domain on cPKC βI, PMA facilitates its translocation to the cell membrane and its subsequent activation. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 binds to the C1 domain of cPKC βI, similar to DAG and PMA. It activates cPKC βI by promoting its translocation to the cell membrane and enhancing the phosphorylation of downstream targets involved in cellular proliferation and differentiation. | ||||||
Ingenol 3-angelate | 75567-37-2 | sc-364214 sc-364214A | 1 mg 5 mg | $189.00 $734.00 | 3 | |
Ingenol Mebutate is an activator of cPKC βI through its interaction with the C1 domain, leading to membrane translocation and activation of cPKC βI. This activation results in the modulation of transcription factors and inflammatory pathways. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin is a non-tumor promoting phorbol ester that binds to the C1 domain of cPKC βI, leading to its activation and the regulation of cPKC βI-mediated signaling pathways involved in cell growth and apoptosis. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 is a synthetic analog of DAG that selectively activates cPKC βI by mimicking the natural ligand, leading to membrane association and kinase activation. This activation triggers downstream signaling involved in various cellular processes. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM I is a selective inhibitor of PKC, but paradoxically, at low concentrations, it can act as an activator of cPKC βI by subtly altering the conformation of the enzyme, thereby enhancing kinase activity toward its substrates. | ||||||
(−)-Indolactam V | 90365-57-4 | sc-202182 sc-202182A | 300 µg 1 mg | $175.00 $350.00 | 1 | |
Indolactam V selectively activates cPKC βI by binding to the C1 domain, leading to a conformational change that results in membrane translocation and activation, thereby influencing cellular proliferation and differentiation. | ||||||
Deoxycholic acid | 83-44-3 | sc-214865 sc-214865A sc-214865B | 5 g 25 g 1 kg | $37.00 $67.00 $941.00 | 4 | |
Deoxycholic acid, a bile acid, can indirectly activate cPKC βI by disrupting cellular membranes and facilitating the translocation of cPKC βI to the membrane, where it becomes active and can phosphorylate its target proteins. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a fatty acid that can modulate cPKC βI activity by altering membrane fluidity and potentially enhancing the interaction between cPKC βI and its lipid cofactors, leading to its activation. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine serves as a lipid second messenger that can enhance cPKC βI activity by promoting its association with the plasma membrane, where cPKC βI becomes active and participates in the regulation of cellular responses. | ||||||