Coronin 1B Activators
Coronin 1B Activators is a theoretical class of compounds that can directly or indirectly influence the activity of Coronin 1B, a protein that plays an important role in regulating actin dynamics. No direct chemical activators of Coronin 1B are identified, so this class currently includes only compounds that can indirectly influence Coronin 1B function by modulating general cellular processes involving the actin cytoskeleton. The compounds identified here include those that affect actin polymerization, such as Jasplakinolide, Cytochalasin D, Phalloidin, Latrunculin A, and Swinholide A; those that inhibit the Arp2/3 complex, such as CK-666 and CK-869; those that inhibit the forminproteins involved in actin polymerization, such as SMIFH2; and those that modulate the activity of proteins involved in actin-myosin interaction, such as Y-27632, Blebbistatin, ML-7, and H-1152P.
By modulating the actin dynamics, these compounds can indirectly influence the activity of Coronin 1B, which is known to regulate the Arp2/3 complex-mediated actin polymerization and other actin-related processes. For example, Jasplakinolide enhances actin polymerization, thus indirectly affecting Coronin 1B by altering the actin dynamics that Coronin 1B is involved in. Similarly, CK-666 and CK-869 can indirectly affect the activity of Coronin 1B by inhibiting the Arp2/3 complex, which Coronin 1B is known to regulate. Compounds such as Y-27632, Blebbistatin, ML-7, and H-1152P modulate the actin-myosin interaction, which is a key process in actin cytoskeleton regulation. By affecting this interaction, these compounds can indirectly influence the function of Coronin 1B, which is involved in actin cytoskeleton dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is a cell-permeable macrocyclic peptide that stabilizes actin filaments and enhances actin polymerization. It indirectly affects Coronin 1B by modulating the actin dynamics that Coronin 1B is involved in regulating. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an actin polymerization inhibitor that can indirectly affect the function of Coronin 1B by preventing the formation of actin filaments that Coronin 1B binds to and regulates. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin is a potent toxin that binds to actin filaments and stabilizes them, preventing their depolymerization. This can indirectly affect Coronin 1B by altering the actin dynamics that Coronin 1B is involved in. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is a toxin that binds to actin monomers and prevents their polymerization, thus indirectly affecting the actin dynamics that Coronin 1B regulates. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A is a marine toxin that severs actin filaments, thus altering the actin dynamics that Coronin 1B is involved in. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which is involved in actin polymerization. By inhibiting this complex, CK-666 can indirectly affect the activity of Coronin 1B, which is known to regulate the Arp2/3 complex. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is another inhibitor of the Arp2/3 complex. Like CK-666, it can indirectly influence the function of Coronin 1B. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of the formin proteins, which are involved in actin polymerization. It can indirectly affect the activity of Coronin 1B by modulating the actin dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinases (ROCK), which are involved in actin cytoskeleton regulation. It can indirectly influence Coronin 1B function by altering the actin dynamics. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is an inhibitor of myosin II, a motor protein that interacts with actin. It can indirectly affect the activity of Coronin 1B by affecting the actin-myosin interaction. | ||||||