Molecular structure of CK-869, CAS Number: 388592-44-7
CK-869 (CAS 388592-44-7)
Alternate Names:
CK-0157869; 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
CAS Number:
388592-44-7
Molecular Weight:
394.3
Molecular Formula:
C17H16BrNO3S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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CK-869 (CAS 388592-44-7) References
- Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. | Hetrick, B., et al. 2013. Chem Biol. 20: 701-12. PMID: 23623350
- Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells. | Ilatovskaya, DV., et al. 2013. Cell Tissue Res. 354: 783-92. PMID: 24036843
- Structure and Function of an Actin-Based Filter in the Proximal Axon. | Balasanyan, V., et al. 2017. Cell Rep. 21: 2696-2705. PMID: 29212018
- Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. | Yamagishi, Y., et al. 2018. Biochem Biophys Res Commun. 496: 834-839. PMID: 29395083
- Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression. | Plessner, M., et al. 2019. iScience. 15: 274-281. PMID: 31096079
- An actin-WHAMM interaction linking SETD2 and autophagy. | Seervai, RNH., et al. 2021. Biochem Biophys Res Commun. 558: 202-208. PMID: 33036756
- Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development. | Pocaterra, A., et al. 2021. Commun Biol. 4: 763. PMID: 34155338
- Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. | Endo, Y., et al. 2022. J Virus Erad. 8: 100307. PMID: 36514715
- The Arp2/3 complex enhances cell migration on elastic substrates. | Mair, DB., et al. 2023. Mol Biol Cell. 34: ar67. PMID: 36989030
- Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia. | Yasuta, Y., et al. 2024. Sci Rep. 14: 1525. PMID: 38233537
Inhibitor of:
α-actinin-3, γPAK, ACTC1, ACTG2, Actin related protein 2/3 (ARP2/3), Adducin β, ANK-1, Arp2, Arp3β, beta-Actin, Calponin 2, Cofilin 1, DENND1A, Ezrin, FAM21B, FBP21, Flightless I, INF2, L-Plastin, Las17, LRRC16B, MRTF-B, MYBPH, MYH4, MYH6, MYH7, Myosin Ic, Myosin Ig, Myosin Va, Myosin X, periaxin, Profilin, Rab 3A, Smooth Muscle Actin, Tmsb15b1, TOCA-1, Tropomyosin 4, Troponin I-FS, UNC45B, Villin, VPS13A, WNT (Wingless Int-1), Wnt-5a, and Zyxin.Activator of:
Arp3C, ARPC5L, BC055107, Cdc42EP4, Cofilin 1, Coronin 1B, Coronin 7, DAAM2, Dynactin 1, KLHL38, LIMK-1, MRTF-A, Myosin VI, Myosin XVIIIb, tropomodulin 3, and Twinfilin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CK-869, 5 mg | sc-507274 | 5 mg | $163.00 |