COMMD1 Activators
COMMD1 activators are a group of chemical agents that target the protein COMMD1-a multifaceted protein involved in various cellular processes, including the regulation of copper homeostasis, sodium transport, and the degradation of specific proteins via the ubiquitin-proteasome system. As a crucial component of the cellular machinery, COMMD1 interacts with diverse proteins and is implicated in the modulation of NF-κB signaling, an essential pathway for inflammatory responses and cellular survival.
Activators of COMMD1 can work through several mechanisms. Direct activators might bind to COMMD1 and induce conformational changes that enhance its stability or its interaction with other proteins, such as those forming part of the COMMD/CCDC22/CCDC93 (CCC) complex, thereby facilitating its role in protein trafficking and degradation. This binding could also promote COMMD1's ability to bind to copper, subsequently enhancing its function in copper metabolism. Alternatively, indirect activators might upregulate the expression of the COMMD1 gene, leading to increased protein levels within the cell, or stabilize the protein post-translationally, preventing its degradation. They may also influence the signaling pathways that COMMD1 is known to regulate, such as NF-κB, by modulating the activity of upstream or downstream components, thereby indirectly enhancing the functional output of COMMD1. Scientific research into COMMD1 activators is driven by the endeavor to understand the protein's role in cellular physiology and the complex networks it operates within. By employing such activators in experimental settings, researchers can dissect the pathways and interactions that COMMD1 influences. This involves assessing changes in protein-protein interactions, monitoring alterations in gene expression profiles, and evaluating the effects on copper homeostasis and NF-κB activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $18.00 $23.00 $35.00 $65.00 | 15 | |
Sodium Chloride is involved in maintaining osmotic balance and can lead to activation of COMMD1. COMMD1 plays a role in sodium reabsorption in the kidney, and increased sodium levels can stimulate this function. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Ammonium chloride can enhance the functional activity of COMMD1. COMMD1 is involved in protein trafficking and degradation, and the presence of ammonium chloride, which is known to influence these processes, can stimulate COMMD1’s function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide can block protein synthesis which can indirectly enhance the functional activity of COMMD1. This compound prevents the assembly of new proteins, leading to the upregulation of protein degradation pathways, in which COMMD1 plays a role. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a potent inhibitor of the proteasome. By inhibiting the proteasome, MG132 can enhance the functional activity of COMMD1, which is involved in protein degradation processes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can inhibit lysosomal function, leading to an upregulation of protein degradation pathways that COMMD1 is involved in, thereby enhancing its functional activity. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits the vacuolar-type H+-ATPase, which can enhance the functional activity of COMMD1, as it plays a role in protein trafficking and degradation pathways that can be influenced by this compound. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin sodium is a sodium ionophore and can enhance the functional activity of COMMD1. COMMD1 is involved in sodium reabsorption processes, which can be stimulated by the presence of this compound. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker. By affecting calcium homeostasis, it can indirectly enhance the functional activity of COMMD1, which is known to be involved in ion transport pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Vanadate is a phosphatase inhibitor. By inhibiting phosphatases, vanadate can indirectly enhance the functional activity of COMMD1, which is involved in protein trafficking and degradation. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, a process known to affect protein trafficking. This process is a part of COMMD1's functionality, thus, the presence of tunicamycin can lead to an enhancement of COMMD1's functional activity. | ||||||