COMMD1 Antibody (B-3): sc-518177
- COMMD1 Antibody (B-3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 41-180 mapping near the C-terminus of COMMD1 of human origin
- recommended for detection of COMMD1 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-518177 X, 200 µg/0.1 ml)
- Anti-COMMD1 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for COMMD1 Antibody (B-3) for WB applications. These reagents are now offered in bundles with COMMD1 Antibody (B-3) (see ordering information below).
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COMMD1 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects COMMD1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-COMMD1 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COMMD1, also known as copper metabolism MURR1 domain-containing protein 1, plays a crucial role in copper homeostasis, which is vital for numerous enzymatic processes in living organisms. COMMD1′s function in facilitating biliary copper excretion within hepatocytes is particularly important, as dysregulation of copper metabolism can lead to severe conditions such as Menkes disease, characterized by copper deficiency, or Wilson disease, marked by copper accumulation. COMMD1 is composed of 190 amino acids and is localized in both the nucleus and cytoplasm, with highest expression levels found in liver tissue, and lower levels in lung, heart, kidney, and brain. COMMD1 interacts directly with COMMD6 and ATP7B, and has indirect interactions with IκB-β and COMMD7, highlighting COMMD1′s role in a network of protein-protein interactions essential for maintaining cellular copper balance. All ten members of the COMMD family, including COMMD1, share a conserved COMM domain that facilitates these interactions, underscoring COMMD1′s importance in cellular function and health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COMMD1 Antibody (B-3) References:
- The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. | Klomp, AE., et al. 2003. J Hepatol. 39: 703-9. PMID: 14568250
- COMMD proteins, a novel family of structural and functional homologs of MURR1. | Burstein, E., et al. 2005. J Biol Chem. 280: 22222-32. PMID: 15799966
- The many faces of the copper metabolism protein MURR1/COMMD1. | de Bie, P., et al. 2005. J Hered. 96: 803-11. PMID: 16267171
- COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology. | Coronado, VA., et al. 2005. Clin Genet. 68: 548-51. PMID: 16283886
- Solution structure of the COMMD1 N-terminal domain. | Sommerhalter, M., et al. 2007. J Mol Biol. 365: 715-21. PMID: 17097678
- Characterization and copper binding properties of human COMMD1 (MURR1). | Narindrasorasak, S., et al. 2007. Biochemistry. 46: 3116-28. PMID: 17309234
- Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B. | de Bie, P., et al. 2007. Gastroenterology. 133: 1316-26. PMID: 17919502
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COMMD1 Antibody (B-3) | sc-518177 | 200 µg/ml | $322.00 | |||
COMMD1 Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-550703 | 200 µg Ab; 10 µg BP | $361.00 | |||
COMMD1 Antibody (B-3): m-IgG1 BP-HRP Bundle | sc-550704 | 200 µg Ab; 20 µg BP | $361.00 | |||
COMMD1 Antibody (B-3) X | sc-518177 X | 200 µg/0.1 ml | $322.00 | |||
COMMD1 Antibody (B-3) AC | sc-518177 AC | 500 µg/ml, 25% agarose | $424.00 | |||
COMMD1 Antibody (B-3) HRP | sc-518177 HRP | 200 µg/ml | $322.00 | |||
COMMD1 Antibody (B-3) FITC | sc-518177 FITC | 200 µg/ml | $336.00 | |||
COMMD1 Antibody (B-3) PE | sc-518177 PE | 200 µg/ml | $349.00 | |||
COMMD1 Antibody (B-3) Alexa Fluor® 488 | sc-518177 AF488 | 200 µg/ml | $364.00 | |||
COMMD1 Antibody (B-3) Alexa Fluor® 546 | sc-518177 AF546 | 200 µg/ml | $364.00 | |||
COMMD1 Antibody (B-3) Alexa Fluor® 594 | sc-518177 AF594 | 200 µg/ml | $364.00 | |||
COMMD1 Antibody (B-3) Alexa Fluor® 647 | sc-518177 AF647 | 200 µg/ml | $364.00 | |||
COMMD1 Antibody (B-3) Alexa Fluor® 680 | sc-518177 AF680 | 200 µg/ml | $364.00 | |||
COMMD1 Antibody (B-3) Alexa Fluor® 790 | sc-518177 AF790 | 200 µg/ml | $364.00 |