COL9A2 Inhibitors
COL9A2 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the Collagen Type IX Alpha 2 Chain (COL9A2) protein. COL9A2 is a crucial component of collagen type IX, a structural protein found in the extracellular matrix of various tissues, including cartilage and intervertebral discs. Collagen type IX contributes to the stability and integrity of these tissues and plays a significant role in maintaining their structural properties. Inhibitors of COL9A2 are developed to interact with this specific collagen protein, disrupting its functions related to extracellular matrix organization and tissue structure.
These inhibitors are typically small molecules or compounds designed to bind to COL9A2, interfering with its interactions with other extracellular matrix components or affecting its structural stability. By doing so, COL9A2 inhibitors may impact the overall organization and function of collagen type IX within the extracellular matrix, affecting the mechanical properties and structural integrity of tissues rich in this collagen. Research into COL9A2 inhibitors can provide valuable insights into the role of collagen type IX in tissue physiology and the mechanisms underlying extracellular matrix maintenance, contributing to a better understanding of tissue development and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C crosslinks DNA, potentially limiting the transcription of various genes, including COL9A2, by hindering RNA polymerase access. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide blocks peptide elongation during protein synthesis, which could indirectly affect the synthesis of COL9A2. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting transcription and potentially decreasing COL9A2 mRNA synthesis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid can modulate gene expression and has been shown to regulate collagen synthesis, potentially affecting COL9A2. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to GC-rich DNA sequences, potentially preventing transcription factors from accessing the COL9A2 promoter. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts topoisomerase-II-mediated DNA replication, possibly affecting COL9A2 expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, leading to DNA damage and potential downregulation of genes like COL9A2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can change chromatin structure and gene expression, possibly affecting COL9A2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA, affecting DNA methylation and gene expression, which could reduce COL9A2 levels. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts, leading to DNA damage and potential disruption of transcription, possibly impacting COL9A2 expression. | ||||||