The COL11A2 protein, intricately crafted by the COL11A2 gene, is a structural component of the collagen XI family. Collagens, as a group, are fundamental proteins that supply strength and support to various tissues across the body, including cartilage, bone, tendon, skin, and the white part of the eye, the sclera. COL11A2, while its exact function continues to be explored, is known to play a pivotal role in the development of the inner ear and eyes. This suggests that COL11A2 might be instrumental in maintaining the structural integrity and normal function of these organs. Mutations in the COL11A2 gene are associated with certain genetic disorders, such as non-syndromic hearing loss and Otospondylomegaepiphyseal dysplasia, which further underlines the importance of this protein in human health and development.
The expression of COL11A2, like many other genes, can be induced or upregulated by specific chemical compounds. These compounds, often referred to as activators, can enhance the production of the COL11A2 protein. They include retinoic acid, Vitamin D3, estradiol, dexamethasone, progesterone, genistein, resveratrol, curcumin, epigallocatechin gallate (EGCG), sulforaphane, quercetin, and kaempferol. Each of these compounds may interact with specific receptors or transcription factors, stimulating an increase in COL11A2 expression. For instance, retinoic acid and Vitamin D3 bind to their respective receptors, retinoic acid receptors and Vitamin D receptors, instigating changes in gene expression. Similarly, estradiol, a form of estrogen, and genistein, an isoflavone, can stimulate COL11A2 expression via interaction with estrogen receptors. Understanding these interactions can provide valuable insights into the intricate dance of gene regulation and protein expression. However, it's crucial to emphasize that further research is needed to elucidate the precise mechanisms through which these compounds induce COL11A2 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a Vitamin A metabolite, can potentially upregulate COL11A2 expression by interacting with retinoic acid receptors that control transcriptional activities. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3, or cholecalciferol, through its interaction with the Vitamin D receptor (VDR), can stimulate an increase in COL11A2 expression as a part of its wider function in controlling gene expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol, a type of estrogen, can potentially stimulate the expression of COL11A2 in tissues where estrogen receptors, crucial for gene expression, are active. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can stimulate an increase in COL11A2 expression by interacting with the glucocorticoid receptor, thus controlling transcriptional activities. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone can potentially stimulate the expression of COL11A2 in tissues where progesterone receptors, crucial for gene expression, are active. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes, has been shown to stimulate an increase in COL11A2 expression as part of its wider function in controlling gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound found in turmeric, is known for its capability to stimulate an increase in COL11A2 expression as part of its wider function in controlling gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, a compound found in green tea, can upregulate COL11A2 expression as a part of its wider function in controlling gene expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, a compound found in cruciferous vegetables, has been demonstrated to stimulate an increase in COL11A2 expression as part of its wider function in controlling gene expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, can upregulate COL11A2 expression as a part of its wider function in controlling gene expression. | ||||||