COASTER Activators
Chemical activators of COASTER include a variety of compounds that can induce its activation through different cellular signaling pathways. Forskolin, known for its ability to increase cyclic AMP (cAMP) levels, directly stimulates the cAMP-dependent pathway, leading to the activation of protein kinase A (PKA). Activated PKA can phosphorylate COASTER, thereby increasing its activity. Similarly, Ionomycin, by elevating intracellular calcium levels, can activate calcium-dependent protein kinases which are capable of targeting COASTER for phosphorylation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), another kinase that can phosphorylate COASTER if it is within the substrate range of PKC. Epidermal Growth Factor (EGF) engages the EGF receptor and initiates a signaling cascade, culminating in the activation of kinases that can act on COASTER.
Additionally, Bradykinin, through its action on G-protein-coupled receptors, activates downstream kinases that can also target COASTER. Insulin, upon binding to its receptor, triggers the PI3K/AKT signaling pathway, which is known for its role in phosphorylating various substrates, including potentially COASTER. Anisomycin is a potent activator of the stress-activated protein kinases, including JNK, which may also lead to the phosphorylation of COASTER. Calyculin A and Okadaic Acid, as inhibitors of protein phosphatases, increase the phosphorylation state of proteins, which could result in the activation of COASTER by preventing its dephosphorylation. A23187, like Ionomycin, raises intracellular calcium and thus can activate kinases that phosphorylate COASTER. Bisindolylmaleimide I (BIM I), through its inhibitory action on PKC, can lead to the activation of alternative pathways that may result in COASTER activation. Lastly, Sphingosine-1-phosphate (S1P) binds to its specific G-protein-coupled receptors and could activate G-protein-coupled receptor kinases, which in turn may phosphorylate and activate COASTER, showcasing the intricate network of signaling pathways that can converge on the activation of this protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels. This increase in calcium can activate calcium-dependent protein kinases which may phosphorylate and activate COASTER if it is a substrate for such kinases. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate and activate COASTER if COASTER is within PKC's substrate scope. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin can activate its G-protein-coupled receptors, leading to downstream signaling events that could include the activation of kinases capable of phosphorylating COASTER. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin receptor activation stimulates the PI3K/AKT signaling pathway, which could lead to the activation of COASTER through phosphorylation by AKT if COASTER is a substrate of AKT. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinases/JNK pathway which may lead to phosphorylation and activation of COASTER if it is a target of these kinases. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins, potentially including COASTER if it is normally dephosphorylated by these phosphatases. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent kinases that may phosphorylate and activate COASTER. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid inhibits protein phosphatases, predominantly PP2A, leading to hyperphosphorylation of proteins, which could include COASTER if it is a substrate for such phosphatases. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
BIM I is a specific inhibitor of PKC; in the context of feedback loops, inhibition of PKC might lead to compensatory activation of alternate pathways that could phosphorylate and activate COASTER. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P binds to its G-protein-coupled receptors, potentially activating G-protein-coupled receptor kinases which in turn could phosphorylate and activate COASTER if it is within their substrate range. | ||||||