COASTER Inhibitors
Chemical inhibitors of COASTER function principally by obstructing its regulatory kinases, which are central to its activity. Alsterpaullone, Roscovitine, Paullone, Kenpaullone, and Indirubin-3'-monoxime are all characterized by their ability to inhibit cyclin-dependent kinases (CDKs), which are essential for cell cycle progression. The inhibition of these kinases can directly disrupt the cell cycle-dependent processes that COASTER is involved with. Similarly, Kenpaullone and Paullone also target GSK-3β, a kinase involved in various signaling pathways. The action of these chemical inhibitors can alter the phosphorylation state of proteins in these pathways, which can be crucial for COASTER's function. For instance, by preventing phosphorylation, these chemicals can constrain the regulatory mechanisms that modulate COASTER activity.
Other inhibitors such as Olomoucine and Purvalanol A specifically target CDKs and can prevent the phosphorylation of proteins that may regulate COASTER's interactions with other cellular components. Staurosporine, with its broad kinase inhibition profile, can reduce COASTER activity by inhibiting kinases responsible for its activation. Isoxazole acts by inhibiting a range of enzymes, which can affect the enzymatic processes necessary for COASTER's function. By contrast, Harmine focuses on inhibiting DYRK1A, a kinase that can phosphorylate substrates interacting with COASTER, thereby impacting COASTER's activity. The adenosine analog 5-Iodotubercidin can inhibit kinases by preventing ATP-dependent activities, which are vital for the function of many proteins, including COASTER. Lastly, SP600125, a JNK inhibitor, can suppress signaling pathways that are potentially regulating COASTER, leading to decreased activity of COASTER within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone inhibits cyclin-dependent kinases (CDKs) which are involved in cell cycle regulation. COASTER may be functionally inhibited by the disruption of cell cycle progression, as its activity could be linked to specific cell cycle phases. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a potent inhibitor of CDKs. By inhibiting these kinases, it could halt the phosphorylation processes necessary for COASTER's function if COASTER's activity is dependent on cell cycle phase or phosphorylation state. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $61.00 $153.00 $231.00 $505.00 | 1 | |
Kenpaullone also inhibits CDKs and GSK-3β. By inhibiting these kinases, it could disrupt signaling pathways or cell cycle stages where COASTER may play a role, leading to functional inhibition. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
This molecule inhibits CDKs and could interrupt the phosphorylation process, which may be vital for COASTER's activity, particularly if COASTER is involved in cell cycle regulation. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is a selective inhibitor of CDKs. The inhibition of these kinases could interfere with the cell cycle or other kinase-dependent pathways that COASTER is involved in, leading to its functional inhibition. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is another CDK inhibitor. It could prevent the phosphorylation of proteins that interact with or regulate COASTER, thereby hindering COASTER's function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of a broad range of protein kinases. It could inhibit kinases that activate COASTER, leading to a decrease in COASTER's functional activity. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Harmine is an inhibitor of DYRK1A, a kinase which may phosphorylate substrates that interact with COASTER. By inhibiting DYRK1A, harmine could inhibit the phosphorylation events necessary for COASTER's function. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $153.00 $464.00 | 20 | |
5-Iodotubercidin is an adenosine analog that inhibits various kinases. It could inhibit the ATP-dependent activities of kinases that are essential for COASTER's function, leading to its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which could be involved in signaling pathways regulating COASTER's function. By inhibiting JNK, SP600125 could suppress downstream signaling that regulates COASTER, leading to functional inhibition. | ||||||