COA1 Inhibitors
COA1 Inhibitors represent a class of chemical compounds designed to impede the functioning of COA1, a protein that plays a crucial role in various cellular processes. The inhibition of COA1 involves a targeted approach to disrupt the protein's activity, which is fundamental to the maintenance of cellular homeostasis. These inhibitors work by directly binding to COA1 or by modulating the signaling pathways and molecular interactions that COA1 is involved in. The result of this inhibition is a decrease in COA1's normal function within the cell. The mechanisms of action can vary among different COA1 inhibitors, with some obstructing the protein's active site and others altering its structure, thereby preventing it from interacting with other cellular components essential for its activity. The specificity of COA1 inhibitors is of paramount importance, as they are designed to selectively target COA1 without affecting other proteins that may have similar structures or functions. This specificity is achieved through the precise molecular design that mirrors the unique aspects of COA1's structure or the specific pathways in which it operates.
The development of COA1 inhibitors is a complex process that involves understanding the precise biological role of COA1. By influencing the pathways that COA1 is directly involved in, these inhibitors can lead to a reduction in the protein's functional activity. For instance, if COA1 is part of a signaling cascade, the inhibitors may prevent the phosphorylation events that are necessary for COA1 to exert its effect within the cell. Alternatively, if COA1 is involved in the regulation of gene expression, inhibitors might prevent it from binding to DNA or interacting with transcriptional machinery. The goal of COA1 inhibitors is to achieve a controlled inhibition that allows for the study of COA1's role in cellular processes without completely abolishing its function, which could have deleterious effects on the cell. In summary, COA1 inhibitors are a chemical class that encompasses a range of compounds with diverse but precise modes of action, all converging on the common goal of attenuating the biological activity of COA1 through direct or indirect means.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $71.00 $163.00 | 1 | |
Mitotane is an adrenolytic compound that decreases production of steroids in the adrenal cortex by disrupting the mitochondrial electron transport chain in which COA1 is involved. This leads to decreased functionality of COA1 by impairing the biosynthesis of adrenocortical hormones. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is a mitochondrial complex I inhibitor that blocks the transfer of electrons from iron-sulfur centers in the complex to ubiquinone. Since COA1 is associated with complex I assembly and function, rotenone's action leads to indirect inhibition of COA1 activity by preventing proper electron transport. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits complex IV of the electron transport chain. By impeding the terminal stage of electron transport, it indirectly affects the activity of COA1, which is important for the proper functioning of the upstream complex I. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A binds to complex III in the electron transport chain, which can cause a back-up of electrons and reactive oxygen species production. This indirectly inhibits COA1 by increasing oxidative stress and potentially damaging proteins associated with the electron transport chain. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin is an inhibitor of ATP synthase (complex V), which creates a feedback inhibition on the electron transport chain. The inhibition of ATP synthase indirectly affects COA1 function by reducing the efficiency of electron transport through complex I where COA1 operates. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Although it primarily targets bacteria, its mechanism can suggest that mitochondrial protein synthesis (similar to bacterial ribosomes) may also be inhibited, potentially affecting COA1 function indirectly. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $62.00 $92.00 $265.00 $409.00 $622.00 | 6 | |
Tetracycline binds to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis. Similar to chloramphenicol, the structural similarity of mitochondrial ribosomes could lead to an indirect decrease in COA1 expression through inhibition of mitochondrial protein synthesis. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $116.00 $330.00 $510.00 $816.00 $1632.00 | 10 | |
Venetoclax is a BCL-2 inhibitor that induces apoptosis. While it does not directly inhibit COA1, the increased apoptosis can lead to decreased COA1 as cells undergoing apoptosis will reduce their mitochondrial functions, including those associated with COA1. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $265.00 | 2 | |
Atovaquone selectively inhibits the cytochrome b component of complex III, which is upstream of COA1 action in complex I. This results in the indirect inhibition of COA1 activity due to disruption of the electron transport chain. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
Zidovudine is a nucleoside analog that can incorporate into mitochondrial DNA, potentially leading to toxicity and mitochondrial dysfunction. This can indirectly inhibit COA1 by impairing mitochondrial genome expression and, consequently, electron transport chain function. | ||||||