CNOT4 Activators
CNOT4 Activators are chemical compounds that directly or indirectly enhance the functional activity of CNOT4, a ubiquitin ligase enzyme that plays a critical role in protein degradation and gene expression. These activators operate through specific signaling pathways or biological processes that CNOT4 is involved in, such as the ubiquitination of proteins, regulation of gene transcription, and cell signaling. Examples of such activators include Epidermal Growth Factor (EGF), which provides more substrate for CNOT4 to ubiquitinate, and Forskolin, which can activate gene expression regulation pathways involving the CCR4-NOT complex, of which CNOT4 is a part.
Other activators, such as 3-Isobutyl-1-methylxanthine (IBMX) and Dexamethasone, enhance CNOT4 activity by affecting cAMP levels and glucocorticoid receptor signaling, respectively, both of which can influence gene expression regulatory pathways involving CNOT4. Similarly, Retinoic Acid can indirectly activate CNOT4 by binding to the retinoic acid receptor (RAR) and influencing gene expression. On the other hand, Staurosporine, a potent inhibitor of protein kinases, may indirectly enhance the activity of CNOT4 by influencing the ubiquitination process in which CNOT4 plays a crucial role. Trichostatin A, a histone deacetylase inhibitor, can impact chromatin structure and gene expression, potentially indirectly activating CNOT4. Lithium Chloride, an inhibitor of glycogen synthase kinase 3 beta (GSK3β), can also influence gene expression, hence indirectly enhancing CNOT4 activity. Similarly, Phorbol 12-Myristate 13-Acetate (PMA), an activator of protein kinase C (PKC), and SU6656, an inhibitor of Src family kinases, can influence various cellular pathways that could indirectly activate CNOT4. Tunicamycin, which inhibits N-linked glycosylation, may increase the demand for protein degradation machinery, thus enhancing the function of CNOT4. Lastly, Bisindolylmaleimide I, a specific inhibitor of PKC, can affect various cellular pathways that potentially activate CNOT4 indirectly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin enhances the activity of adenylate cyclase, increasing cAMP levels. This activates PKA, which can phosphorylate a variety of proteins. CNOT4, being a part of the CCR4-NOT complex, can be indirectly activated by this pathway, as it is involved in gene expression regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor, leading to increased cAMP levels. This may indirectly enhance the activity of CNOT4 by activating gene expression regulation pathways involving the CCR4-NOT complex. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is an active metabolite of vitamin A that binds to the retinoic acid receptor (RAR) and regulates gene expression. CNOT4 could be indirectly activated due to its role in protein ubiquitination and gene expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. Activation of this receptor influences gene expression, and CNOT4, being a part of the CCR4-NOT complex, may be indirectly activated through these pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which may indirectly enhance the activity of CNOT4. By inhibiting protein kinases, the ubiquitination process in which CNOT4 is involved may be enhanced. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, affecting chromatin structure and gene expression. CNOT4, being part of the CCR4-NOT complex involved in gene regulation, may be indirectly activated. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 beta (GSK3β). GSK3β is involved in various cellular processes, including gene expression, where CNOT4 plays a role via the CCR4-NOT complex. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a strong activator of protein kinase C (PKC), which is involved in many signaling pathways. CNOT4 could be indirectly activated due to its role in protein ubiquitination and gene expression. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $56.00 $130.00 | 27 | |
SU6656 is a selective inhibitor of Src family kinases. By inhibiting these kinases, the ubiquitination process in which CNOT4 is involved may be enhanced. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, an essential process for many proteins. This may increase the demand for protein degradation machinery, thus enhancing the function of CNOT4. | ||||||