CNOT4 Inhibitors
The chemical class of CNOT4 inhibitors encompasses a diverse array of compounds, each exerting its inhibitory effects through distinct mechanisms. One prominent group includes neddylation pathway inhibitors, such as MLN4924 and Pevonedistat. These small molecules interfere with the neddylation of cullins, inhibiting the SCF E3 ubiquitin ligase complex responsible for CNOT4 degradation. Consequently, elevated CNOT4 levels impact mRNA deadenylation and turnover processes, providing a targeted approach for modulating CNOT4 activity. Transcription inhibitors, exemplified by Actinomycin D, Actinomycin F1, and Triptolide, indirectly affect CNOT4 by impeding RNA polymerase activity. Binding to DNA or modulating RNA polymerase II, these compounds reduce CNOT4 mRNA synthesis, altering its expression and influencing mRNA metabolism. Similarly, flavopiridol, Alpha-Amanitin, and 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) act as transcriptional regulators by suppressing CDKs or inhibiting RNA polymerase II, offering a specific means to study CNOT4's role in mRNA metabolism.
Natural compounds like Tripterygium wilfordii Hook F extract and Cordycepin provide unique avenues for CNOT4 modulation. Tripterygium wilfordii Hook F extract, containing triptolide, influences transcription, while Cordycepin, a nucleoside analog, interferes with RNA polymerase II, impacting CNOT4 expression and downstream mRNA processes. In summary, the diverse class of CNOT4 inhibitors encompasses compounds targeting neddylation, transcription, and natural products. These tools enable precise control over CNOT4 activity, offering valuable insights into its regulatory role in mRNA metabolism and related cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 inhibits CNOT4 through neddylation pathway interference. It prevents cullin neddylation, hindering the activity of the SCF E3 ubiquitin ligase complex, which targets CNOT4 for degradation. This inhibition leads to increased CNOT4 levels, affecting mRNA deadenylation and turnover processes. MLN4924, by disrupting the ubiquitin-proteasome system, offers a targeted approach for modulating CNOT4 activity and downstream cellular functions. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D, a potent transcription inhibitor, indirectly affects CNOT4 by impeding RNA polymerase activity. By binding to DNA and preventing transcription initiation, it impacts the synthesis of CNOT4 mRNA. This leads to reduced CNOT4 expression, affecting mRNA deadenylation and turnover processes. Actinomycin D, a classic anticancer antibiotic, serves as a valuable tool for investigating CNOT4's regulatory role in mRNA metabolism. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
Nutlin-3, a small molecule inhibitor, indirectly influences CNOT4 through p53 activation. Nutlin-3 disrupts the interaction between MDM2 and p53, stabilizing and activating p53. Activated p53 can transcriptionally regulate CNOT4 expression, impacting mRNA deadenylation and turnover processes. Nutlin-3's modulation of the p53 pathway provides a route to indirectly modulate CNOT4 levels and study its downstream effects on mRNA metabolism. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide, a diterpene triepoxide, indirectly inhibits CNOT4 through transcriptional regulation. It modulates RNA polymerase II activity, reducing CNOT4 mRNA synthesis. This results in altered CNOT4 expression levels, impacting mRNA deadenylation and turnover processes. Triptolide's ability to modulate transcription provides a mechanism for studying the regulatory role of CNOT4 in mRNA metabolism and related cellular functions. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol inhibits CNOT4 through transcriptional regulation. As a cyclin-dependent kinase inhibitor, it suppresses CDK9, hindering RNA polymerase II activity. This reduces CNOT4 mRNA synthesis, impacting CNOT4 expression levels and subsequently influencing mRNA deadenylation and turnover processes. Flavopiridol, with its ability to modulate transcription, provides a specific means to investigate CNOT4's role in regulating mRNA metabolism and related cellular functions. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-Amanitin, a potent transcription inhibitor, indirectly affects CNOT4 by inhibiting RNA polymerase II activity. By binding to RNA polymerase II and preventing transcription elongation, it reduces the synthesis of CNOT4 mRNA. This results in decreased CNOT4 expression, influencing mRNA deadenylation and turnover processes. Alpha-Amanitin, found in the death cap mushroom, serves as a tool for studying CNOT4's regulatory role in mRNA metabolism and related cellular functions. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB indirectly inhibits CNOT4 through transcriptional interference. As a CDK9 inhibitor, it hampers RNA polymerase II activity, reducing CNOT4 mRNA synthesis. This leads to altered CNOT4 expression levels, influencing mRNA deadenylation and turnover processes. DRB, by modulating transcription, offers a specific approach for studying CNOT4's regulatory role in mRNA metabolism and related cellular functions. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin, a natural nucleoside analog, indirectly inhibits CNOT4 through transcriptional interference. It impedes RNA polymerase II activity, reducing CNOT4 mRNA synthesis. This results in altered CNOT4 expression levels, influencing mRNA deadenylation and turnover processes. Cordycepin, found in Cordyceps fungi, serves as a natural compound for investigating CNOT4's regulatory role in mRNA metabolism and related cellular functions. | ||||||