CMTM2b Inhibitors
CMTM2b, a pivotal player in transcription corepressor activity, operates within the cytoplasm and nucleus, orchestrating negative regulation of transcription and testosterone biosynthetic processes. Actinomycin D, a potent RNA polymerase inhibitor, directly targets CMTM2b, disrupting its transcription corepressor activity and influencing cellular processes involved in testosterone regulation. Trichostatin A and SAHA, histone deacetylase inhibitors, modulate CMTM2b, interfering with its transcription corepressor activity and impacting processes related to testosterone biosynthesis.
Etoposide and Camptothecin, inhibitors of topoisomerases, directly influence CMTM2b, disrupting its role in transcription corepressor activity and affecting regulation of testosterone biosynthetic processes. Flavopiridol and Vorinostat provide insights into CMTM2b's modulation through cyclin-dependent kinase and histone deacetylase inhibition, respectively. DNA intercalators such as Doxorubicin and Ellipticine, along with the DNA crosslinking agent Cisplatin, directly target CMTM2b, impacting its transcription corepressor activity and the regulation of testosterone biosynthesis. Azacitidine and 5-Aza-2'-deoxycytidine, DNA methyltransferase inhibitors, serve as direct CMTM2b inhibitors, shedding light on the regulatory mechanisms involved in transcription and testosterone biosynthesis. This diverse array of inhibitors offers a comprehensive understanding of avenues for manipulating CMTM2b function, contributing to our comprehension of essential cellular processes in transcription and hormonal regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D, an RNA polymerase inhibitor, directly targets CMTM2b, disrupting its transcription corepressor activity. This inhibition affects negative regulation of transcription and the regulation of the testosterone biosynthetic process in the cytoplasm and nucleus. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, serves as a direct CMTM2b inhibitor by modulating transcription corepressor activity. This interference disrupts CMTM2b-mediated negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, directly targets CMTM2b, influencing its transcription corepressor activity. This disruption impacts CMTM2b-mediated negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA, also known as Vorinostat, a histone deacetylase inhibitor, serves as a direct CMTM2b inhibitor by modulating transcription corepressor activity. This interference disrupts CMTM2b-mediated negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a DNA topoisomerase I inhibitor, directly targets CMTM2b, disrupting its transcription corepressor activity. This inhibition influences negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol, a cyclin-dependent kinase inhibitor, serves as a direct CMTM2b inhibitor by modulating transcription corepressor activity. This interference disrupts CMTM2b-mediated negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin, a DNA intercalator and topoisomerase II inhibitor, directly targets CMTM2b, impacting its transcription corepressor activity. This disruption influences negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin, a DNA crosslinking agent, directly targets CMTM2b, influencing its transcription corepressor activity. This disruption impacts negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, serves as a direct CMTM2b inhibitor by modulating transcription corepressor activity. This interference disrupts CMTM2b-mediated negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine, a DNA intercalator and topoisomerase II inhibitor, directly targets CMTM2b, impacting its transcription corepressor activity. This disruption influences negative regulation of transcription and regulation of testosterone biosynthetic processes in the cytoplasm and nucleus. | ||||||